The Klondike is a region of the territory of Yukon, in northwestern Canada. It lies around the Klondike River, a small river that enters the Yukon River from the east at Dawson City. The area is merely an informal geographic region, and has no function to the territory as any kind of administrative region. It is located in the traditional territory of the Tr’ondëk Hwëch’in First Nation.

Yukon is the smallest and westernmost of Canada's three territories. It is the third-least populated province or territory in Canada, with a population of 45,148 as of 2023. However, Whitehorse, the territorial capital, is the largest settlement in any of the three territories.