Knightdale is a town in Wake County, North Carolina, United States. As of the 2020 census, Knightdale has a population of 19,435, up from 11,401 in 2010. The U.S. Census Bureau estimates the town's population to be 17,843, as of July 1, 2019. Knightdale's population grew 10.4% from 2010 to 2013, making it the second fastest-growing community in the Research Triangle region for that time period.

U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east–west route through the central and eastern portion of the state.