Knightstown is a town in Wayne Township, Henry County, Indiana, adjacent to Rush County, along the Big Blue River. The population was 2,182 at the 2010 census. It is approximately thirty-two miles east of Indianapolis.

Henry County is a county located in east central Indiana, United States. As of 2020, the population was 48,914. The county seat and largest and only city is New Castle. Henry County is the main setting of the novel Raintree County by Ross Lockridge Jr.