The knowledge of Christ refers to one of two possible, and at times related, topics in Christology: one addresses how Christians come to know Christ, the other focuses on the knowledge of Christ about the world. Discussions regarding the knowledge of Christ have had a central place in Christology for centuries. In the 20th century, the interplay between the two concepts was epitomized in the title of a book by Hans Urs von Balthasar: "Does Jesus Know Us? Do We Know Him?"

In Western Christianity, Lectio Divina is a traditional monastic practice of scriptural reading, meditation and prayer intended to promote communion with God and to increase the knowledge of God's word. In the view of one commentator, it does not treat Scripture as texts to be studied, but as the living word.