Knoxville High School was a public high school in Knoxville, Tennessee, that operated from 1910 to 1951, enrolling grades 10 to 12. Its building is a contributing property in the Emory Place Historic District, which is listed on the National Register of Historic Places. The building was more recently used for adult education programs offered by Knox County Schools.

The Emory Place Historic District is a historic district in Knoxville, Tennessee, United States, located just north of the city's downtown area. The district consists of several commercial, residential, religious, and public buildings that developed around a late nineteenth century train and trolley station. The district includes the Knoxville High School building, St. John's Lutheran Church, First Christian Church, and some of the few surviving rowhouses in Knoxville. The district was listed on the National Register of Historic Places in 1994, with a boundary increase in 2023.