Kocktails with Khloé is an American pop culture–themed variety talk show that premiered on the FYI cable channel on January 20, 2016. The series is hosted by reality television personality Khloé Kardashian. In April 2016, FYI cancelled Kocktails with Khloé after one season.

Khloé Alexandra Kardashian is an American media personality, socialite and model. She rose to fame starring with her family in the reality television series Keeping Up with the Kardashians from 2007 to 2021. Its success led to the creation of spin-offs, including Kourtney and Khloé Take Miami (2009–2013) and Kourtney and Khloé Take The Hamptons (2014–2015). Following the ending of their previous show, she and her family began starring on Hulu's The Kardashians in 2022.