Kusatsu-juku was the fifty-second of the fifty-three stations of the Tōkaidō as well as the sixty-eighth of the sixty-nine stations of the Nakasendō. It is located in the downtown area of the present-day city of Kusatsu, Shiga Prefecture, Japan.

The 53 Stations of the Tōkaidō are the rest areas along the Tōkaidō, which was a coastal route that ran from Nihonbashi in Edo to Sanjō Ōhashi in Kyoto. There were originally 53 government post stations along the Tōkaidō, where travelers had to present traveling permits at each station if wanting to cross.