The Kuskokwim River or Kusko River is a river, 702 miles (1,130 km) long, in Southwest Alaska in the United States. It is the ninth largest river in the United States by average discharge volume at its mouth and seventeenth largest by basin drainage area. The Kuskokwim River is the longest river system contained entirely within a single U.S. state.

Central Alaskan Yupʼik is one of the languages of the Yupik family, in turn a member of the Eskimo–Aleut language group, spoken in western and southwestern Alaska. Both in ethnic population and in number of speakers, the Central Alaskan Yupik people form the largest group among Alaska Natives. As of 2010 Yupʼik was, after Navajo, the second most spoken aboriginal language in the United States. Yupʼik should not be confused with the related language Central Siberian Yupik spoken in Chukotka and St. Lawrence Island, nor Naukan Yupik likewise spoken in Chukotka.