Kwethluk is a city in Bethel Census Area in the U.S. state of Alaska. At the 2010 census the population was 721, up from 713 in 2000. It is the birthplace of Saint Olga of Alaska

Central Alaskan Yupʼik is one of the languages of the Yupik family, in turn a member of the Eskimo–Aleut language group, spoken in western and southwestern Alaska. Both in ethnic population and in number of speakers, the Central Alaskan Yupik people form the largest group among Alaska Natives. As of 2010 Yupʼik was, after Navajo, the second most spoken aboriginal language in the United States. Yupʼik should not be confused with the related language Central Siberian Yupik spoken in Chukotka and St. Lawrence Island, nor Naukan Yupik likewise spoken in Chukotka.