The Kwilu rebellion (1963–1965) was a civil uprising which took place in the West of what is the modern-day Democratic Republic of the Congo. The rebellion took place in the wider context of the Cold War and the Congo Crisis. Led by Pierre Mulele, a follower of ousted Prime Minister Patrice Lumumba, a faction of rebel Maoists staged a revolt against the government in the Kwilu District. Based around the struggle for independence, the rebellion was encouraged by economic, social, and cultural grievances. Supported by communist China, rebels used mainly guerrilla warfare against government forces. The rebellion was concurrent with the Simba rebellion occurring in other areas of the Congo during this time. While the rebellion was suppressed in the early months of 1965, it had lasting political impacts, leading to the dissolution of Kwilu as an official province.

Pierre Mulele was a Congolese rebel active in the Simba rebellion of 1964. Mulele had also been minister of education in Patrice Lumumba's cabinet. With the assassination of Lumumba in January 1961 and the arrest of his recognised deputy Antoine Gizenga one year later, Mulele became one of the top Lumumbists determined to continue the struggle. He went to Cairo as the representative of the Lumumbists' Congo National Liberation Committee based in Brazzaville. From Cairo he proceeded to China in 1963 to receive military training, and also took a group of Congolese youths with him, who received training in guerrilla tactics. Mulele was lured out of exile after Mobutu Sese Seko promised him amnesty, but Mobutu had him tortured and executed after Mulele returned to the Congo. He was a member of the Bapende ethnic group.