The L'Innovation fire was a fire that took place at the À L'Innovation department store on the Rue Neuve/Nieuwstraat in central Brussels, Belgium, on 22 May 1967. More than 150 firefighters were mobilised to fight it, 325 people were killed, 80 injured, and the department store itself, the work of the Art Nouveau architect Victor Horta, was destroyed.

The Art Nouveau movement of architecture and design first appeared in Brussels, Belgium, in the early 1890s, and quickly spread to France and to the rest of Europe. It began as a reaction against the formal vocabulary of European academic art, eclecticism and historicism of the 19th century, and was based upon an innovative use of new materials, such as iron and glass, to open larger interior spaces and provide maximum light; curving lines such as the whiplash line; and other designs inspired by plants and other natural forms.