The Lötschberg is an Alpine mountain massif, usually associated with a major, historically important transit axis of the Alps in Switzerland with, at its core, the Lötschen Pass. The mountain pass, which culminates at nearly 2,700 metres above sea level, are part of the eastern Bernese Alps, whose main crest straddles the border between the cantons of Bern and Valais. The valleys concerned by the Lötschberg are those of the Kander in the Berner Oberland, with Kandersteg at the head of it, and a secluded side-valley of the Upper Valais, the Lötschental, with Ferden at the valley's entrance and at the bottom of the pass.

The Gotthard Pass or St. Gotthard Pass at 2,106 m (6,909 ft) is a mountain pass in the Alps traversing the Saint-Gotthard Massif and connecting northern Switzerland with southern Switzerland. The pass lies between Airolo in the Italian-speaking canton of Ticino, and Andermatt in the German-speaking canton of Uri, and connects further Bellinzona and Lugano to Lucerne, Basel, and Zürich. The Gotthard Pass lies at the heart of the Gotthard, a major transport axis of Europe, and it is crossed by three traffic tunnels, each being the world's longest at the time of their construction: the Gotthard Rail Tunnel (1882), the Gotthard Road Tunnel (1980) and the Gotthard Base Tunnel (2016). With the Lötschberg to the west, the Gotthard is one of the two main north-south routes through the Swiss Alps.