Laâyoune-Sakia El Hamra is one of the twelve regions of Morocco. It is mainly located in the disputed territory of Western Sahara: the western part of the region is administered by Morocco and the eastern part by the Sahrawi Arab Democratic Republic. The region as claimed by Morocco covers an area of 140,018 square kilometres (54,061 sq mi) and had a population of 367,758 as of the 2014 Moroccan census. The capital of the region is Laâyoune.

Regions are currently the highest administrative divisions in Morocco. Since 2015, Morocco officially administers 12 regions, including one that lies completely within the disputed territory of Western Sahara and two that lie partially within it. The regions are subdivided into a total of 75 second-level administrative divisions, which are prefectures and provinces.