LaSalle or La Salle is a city in LaSalle County, Illinois, United States, located at the intersection of Interstates 39 and 80. It is part of the Ottawa, IL Micropolitan Statistical Area. Originally platted in 1837 over one square mile, the city's boundaries have grown to 12 sq mi (31 km2). City boundaries extend from the Illinois River and Illinois and Michigan Canal to a mile north of Interstate 80 and from the city of Peru on the west to the village of North Utica on the east. Starved Rock State Park is located approximately 5 mi (8 km) to the east. The population was 9,582 as of the 2020 census, down from 9,609 at the 2010 census. LaSalle and its twin city, Peru, make up the core of the Illinois Valley. Due to their combined dominance of the zinc processing industry in the early 1900s, they were collectively nicknamed "Zinc City."

The Illinois River is a principal tributary of the Mississippi River at approximately 273 miles (439 km) in length. Located in the U.S. state of Illinois, the river has a drainage basin of 28,756.6 square miles (74,479 km2). The Illinois River begins with the confluence of the Des Plaines and Kankakee rivers in the Chicago metropolitan area, and it generally flows to the southwest across Illinois, until it empties into the Mississippi near Grafton, Illinois. Its drainage basin extends into southeastern Wisconsin, northwestern Indiana, and a very small area of southwestern Michigan in addition to central Illinois. Along its shores are several river ports, including Peoria, Illinois. Historic and recreation areas on the river include Starved Rock, and the internationally important wetlands of the Emiquon Complex and Dixon Waterfowl Refuge.