LaSalle or La Salle is a city in LaSalle County, Illinois, United States, located at the intersection of Interstates 39 and 80. It is part of the Ottawa, IL Micropolitan Statistical Area. Originally platted in 1837 over one square mile, the city's boundaries have grown to 12 sq mi (31 km2). City boundaries extend from the Illinois River and Illinois and Michigan Canal to a mile north of Interstate 80 and from the city of Peru on the west to the village of North Utica on the east. Starved Rock State Park is located approximately 5 mi (8 km) to the east. The population was 9,582 as of the 2020 census, down from 9,609 at the 2010 census. LaSalle and its twin city, Peru, make up the core of the Illinois Valley. Due to their combined dominance of the zinc processing industry in the early 1900s, they were collectively nicknamed "Zinc City."

LaSalle County is located within the Fox Valley and Illinois River Valley regions of the U.S. state of Illinois. As of the 2020 Census, it had a population of 109,658. Its county seat and largest city is Ottawa. LaSalle County is part of the Ottawa, IL Micropolitan Statistical Area of Northern Illinois.