The LaSalle Expressway is a 2.62-mile-long (4.22 km) freeway in Niagara County, New York, in the United States. It begins near the North Grand Island Bridge at an interchange with Interstate 190 (I-190) in Niagara Falls and ends just south of the Niagara Falls International Airport at Williams Road (NY 952V) in Wheatfield. The LaSalle Expressway is part of New York State Route 951A (NY 951A), an unsigned reference route; the other, 0.42-mile (0.68 km) portion is located along Niagara Street between the Rainbow Bridge and Fifth Street in downtown Niagara Falls. Most of this portion, which is not connected to the LaSalle Expressway, is also part of the signed NY 384.

Niagara County is in the U.S. state of New York. As of the 2020 census, the population was 212,666. The county seat is Lockport. The county name is from the Iroquois word Onguiaahra; meaning the strait or thunder of waters. The county is part of the Western New York region of the state.