LaSalle Parish is a parish located in the U.S. state of Louisiana. As of the 2020 United States Census, the population was 14,791. The parish seat is Jena. The parish was created in 1910 from the western section of Catahoula Parish.

René-Robert Cavelier, Sieur de La Salle, was a 17th-century French explorer and fur trader in North America. He explored the Great Lakes region of the United States and Canada, and the Mississippi River. He is best known for an early 1682 expedition in which he canoed the lower Mississippi River from the mouth of the Illinois River to the Gulf of Mexico; there, on 9 April 1682, he claimed the Mississippi River basin for France after giving it the name La Louisiane. One source states that "he acquired for France the most fertile half of the North American continent". A later ill-fated expedition to the Gulf coast of Mexico gave the United States a claim to Texas in the purchase of the Louisiana Territory from France in 1803. La Salle was assassinated in 1687 during that expedition.