La Grange is a city in Lewis County, Missouri, United States. The population was 825 at the 2020 census. Since the 1960 census, the population has been dwindling. It is part of the Quincy, IL–MO Micropolitan Statistical Area.

The Quincy–Hannibal, IL–MO Combined Statistical Area, as defined by the United States Census Bureau, is an area consisting of one county in Western Illinois and three counties in northeast Missouri, anchored by the cities of Quincy and Hannibal.