La Marque High School is a public high school in La Marque, Texas, United States in Greater Houston. The school, which serves grades 9 through 12, is a part of the Texas City Independent School District (TCISD); prior to July 1, 2016, the school district was a part of the La Marque Independent School District (LMISD). After TCISD annexed LMISD, the school remained open, and its athletic teams continued to be separate from those of Texas City High School.

La Marque is a city in Galveston County, Texas, United States, south of Houston. The city population in 2020 was 18,030. La Marque experienced considerable growth in the 1950s, during which the city provided a general administrative and trades and crafts workforce helping to support the petrochemical complex in adjoining Texas City. It is the hometown of U.S. Senator Kay Bailey Hutchison and Norman Bulaich.