La Mitis is a regional county municipality in the Bas-Saint-Laurent region in eastern Quebec, Canada on the Gaspé peninsula. It is named for the Mitis River which has its source in the region and flows through the central part of the region before emptying into the Saint Lawrence River.

The Mitis River is a salmon river in the Bas-Saint-Laurent region of Quebec, Canada. It flows to the south shore of the Saint Lawrence River. There are two hydroelectric dams on the river at a point where a waterfall used to prevent salmon from going further upstream. A system to capture and transport salmon upstream was installed in 1965, and the river now has a healthy salmon population along its whole length.