La Plata is a city in Macon County, Missouri, United States. The population was 1,257 at the 2020 census, down from 1,366 in 2010. La Plata is located next to the Adair County line and is on a mainline of the BNSF Railway. The town is best known for La Plata station, which provides passenger rail service to Chicago and Los Angeles.

Macon County is a county located in the northern portion of the U.S. state of Missouri. As of the 2020 census, the population was 15,209. Its county seat is Macon. The county was organized January 6, 1837, and named for Nathaniel Macon, a Revolutionary War hero and North Carolina politician.