The Lackawaxen River is a 31.3-mile-long (50.4 km) tributary of the Delaware River in northeastern Pennsylvania in the United States. The river flows through a largely rural area in the northern Pocono Mountains, draining an area of approximately 598 square miles (1,550 km2).

The Pocono Mountains, commonly referred to as the Poconos, are a geographical, geological, and cultural region in Northeastern Pennsylvania. They overlook the Delaware River and Delaware Water Gap to the east, Lake Wallenpaupack to the north, Wyoming Valley and the Coal Region to the west, and the Lehigh Valley to the south. The name Pocono is derived from the Munsee word Pokawachne, which means "Creek Between Two Hills".