Lacson Avenue is the principal northwest–southeast artery located in Sampaloc district in northern Manila, Philippines. It is a 6-8 lane median divided avenue that runs approximately 2.9 kilometers (1.8 mi) from Tayuman Street in Santa Cruz to Nagtahan Interchange. It is a component of Circumferential Road 2 of the Manila arterial road network and N140 of the Philippine highway network.

Sampaloc is a district of Manila, Philippines. It is referred to as the University Belt or simply called "U-Belt" for numerous colleges and universities are found within the district such as the University of Santo Tomas, the oldest extant university in Asia; the National University, the first private nonsectarian and coeducational institution in the Philippines; the Far Eastern University, known for its Art Deco campus and cultural heritage site of the Philippines; and the University of the East, once dubbed as the largest university in Asia in terms of enrollment. The district is bordered by the districts of Quiapo and San Miguel in the south, Santa Mesa district in the south and east, Santa Cruz district in the west and north, and Quezon City in the northeast.