Lafayette Street is a major north–south street in New York City's Lower Manhattan. It originates at the intersection of Reade Street and Centre Street, one block north of Chambers Street. The one-way street then successively runs through Chinatown, Little Italy, NoLIta, and NoHo and finally, between East 9th and East 10th streets, merges with Fourth Avenue. A buffered bike lane runs outside the left traffic lane. North of Spring Street, Lafayette Street is northbound (uptown)-only; south of Spring Street, Lafayette is southbound (downtown)-only.

Centre Street is a north–south street in the New York City borough of Manhattan, running through the Civic Center, Chinatown, and Little Italy neighborhoods of Lower Manhattan. It connects Park Row to the south with Spring Street to the north, where it merges with Lafayette Street. Centre Street carries northbound traffic north of Reade Street and two-way traffic between Reade Street and the Brooklyn Bridge.