Lafayette Street is a major north–south street in New York City's Lower Manhattan. It originates at the intersection of Reade Street and Centre Street, one block north of Chambers Street. The one-way street then successively runs through Chinatown, Little Italy, NoLIta, and NoHo and finally, between East 9th and East 10th streets, merges with Fourth Avenue. A buffered bike lane runs outside the left traffic lane. North of Spring Street, Lafayette Street is northbound (uptown)-only; south of Spring Street, Lafayette is southbound (downtown)-only.

Nolita, sometimes written as NoLIta and deriving from "North of Little Italy", is a neighborhood in the borough of Manhattan in New York City. Nolita is situated in Lower Manhattan, bounded on the north by Houston Street, on the east by the Bowery, on the south roughly by Broome Street, and on the west by Lafayette Street. It lies east of SoHo, south of NoHo, west of the Lower East Side, and north of Little Italy and Chinatown.