Lake City is a city in Craighead County, Arkansas, United States, along the St. Francis River. Lake City is one of two county seats in Craighead County. The population was 2,326 as of the 2020 census. It is included in the Jonesboro, Arkansas Metropolitan Statistical Area.

Craighead County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 111,231. The county has two county seats — Jonesboro and Lake City. Craighead County is Arkansas's 58th county, formed on February 19, 1859, and named for state Senator Thomas Craighead. It is one of several dry counties within the state of Arkansas, in which the sale of alcoholic beverages is largely prohibited.