Lake Wylie is a census-designated place (CDP) in York County, South Carolina, United States. The population was 8,841 at the 2010 census. Lake Wylie is located on a peninsula along the shore of Lake Wylie, a reservoir that was named for Dr. W. Gil Wylie in 1960. It is a suburb of Charlotte, North Carolina.

York County is a county on the north central border in the U.S. state of South Carolina. As of the 2020 census, the population was 282,090, making it the seventh-most populous county in the state. Its county seat is the city of York, and its most populous community is Rock Hill. The county is served by one Interstate Highway, Interstate 77.