Lancaster station is an Amtrak railroad station and a former Pennsylvania Railroad station in Lancaster, Lancaster County in the U.S. state of Pennsylvania. Located on the Keystone Corridor, the station is served by the Keystone Service between New York City and Harrisburg, and by the Pennsylvanian between New York and Pittsburgh. Lancaster is the second busiest Amtrak station in Pennsylvania, and the twenty-first busiest in the United States. It is one of the busiest Amtrak stations serving a metropolitan area smaller than two million people, primarily because of the large number of passengers traveling to and from Philadelphia and points east.

Lancaster is a city in and the county seat of Lancaster County, Pennsylvania, and one of the oldest inland cities in the United States. With a population of 58,039 at the 2020 census, it is the tenth-most-populous city in the state. The Lancaster metropolitan area population is 552,984, making it the second largest in the South Central Pennsylvania area.