Laramie County is a county located at the southeast corner of the state of Wyoming. As of the 2020 United States Census, the population was 100,512 or 17.4% of the state's total 2020 population, making it the most populous county in Wyoming, but the least populous county in the United States to be the most populous in its state.

Cheyenne is the capital and most populous city of the U.S. state of Wyoming, as well as the county seat of Laramie County, with 65,132 residents, per the 2020 census. It is the principal city of the Cheyenne metropolitan statistical area which encompasses all of Laramie County and had 100,512 residents as of the 2020 census. Local residents named the town for the Cheyenne Native American people in 1867 when it was founded in the Dakota Territory. Along with Oklahoma City, Oklahoma and Topeka, Kansas, Cheyenne is one of three state capitals with an indigenous name in a state with an indigenous name.