Larkana is a city located in the Sindh province of Pakistan. It is the 15th largest city of Pakistan by population. It is home to the Indus Valley civilization site Mohenjo-daro. The historic Indus River flows in east and south of the city.

Mohenjo-daro is an archaeological site in Larkana District, Sindh, Pakistan. Built c. 2500 BCE, it was the largest settlement of the ancient Indus Valley Civilisation, and one of the world's earliest major cities, contemporaneous with the civilizations of ancient Egypt, Mesopotamia, Minoan Crete, and Norte Chico.