Last Chance is an unincorporated community in Washington County, Colorado, United States. Last Chance is situated at the intersection of U.S. Highway 36 and State Highway 71 in a sparsely populated area of northeastern Colorado. The town was supposedly so named because it was once the only place for travelers to secure fuel and provisions for many miles in any direction. The U.S. Post Office at Woodrow now serves Last Chance postal addresses.

Washington County is a county located in the eastern side of the U.S. state of Colorado. As of the 2020 census, the population was 4,817, making it the least populous “Washington County” in the United States. The county seat is Akron. The county was named in honor of the United States President George Washington.