Late Night with David Letterman is an American late-night talk show hosted by David Letterman on NBC, the first iteration of the Late Night franchise. It premiered on February 1, 1982, and was produced by Letterman's production company, Space Age Meats, and Carson Productions. Letterman had previously hosted his own morning talk show on NBC from June to October 1980. The show's house band, The World's Most Dangerous Band, was led by music director Paul Shaffer. In 1993, Letterman announced that he would leave NBC to host the Late Show with David Letterman on CBS. The final episode of Late Night was broadcast on June 25, 1993. The series has continued as Late Night with Conan O'Brien, Late Night with Jimmy Fallon and Late Night with Seth Meyers.

A late-night talk show is a genre of talk show, originating in the United States. It is generally structured around humorous monologues about the day's news, guest interviews, comedy sketches and music performances. It is characterized by spontaneous conversation, and for an effect of immediacy and intimacy as if the host were speaking directly to each member of the watching audience. Late-night talk shows are also fundamentally shaped by the personality of the host.