1.
Cistus ladanifer
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Cistus ladanifer is a species of flowering plant in the family Cistaceae. It is native to the western Mediterranean region, common names include gum rockrose, laudanum, labdanum, common gum cistus, and brown-eyed rockrose. It is a shrub growing 1–2.5 m tall and wide, the leaves are evergreen, lanceolate, 3–10 cm long and 1–2 cm broad, dark green above and paler underneath. The flowers are 5–8 cm diameter, with 5 papery white petals, usually with a red to maroon spot at the base, surrounding the yellow stamens and pistils. The whole plant is covered with the exudate of fragrant resin. C. ladanifer is particularly suited to the Continentalized Mediterranean climate. It is an aggressive plant which has taken over much of former farmland and grasslands in the mountain regions of central Spain. In Spanish it is known as Jara pringosa meaning sticky shrub, in Portuguese it is known as esteva. It has been found to have associations with Boletus edulis, Boletus rhodoxanthus. C. ladanifer is placed within the C. salvifolius group within white, the wide distribution and morphological variation of C. ladanifer across northern Africa, the Iberian peninsula, and southern France has resulted in the recognition of three sub-species, subspp. Although its seeds fall close to the plant, C. ladanifer may have successfully dispersed due to its preference for disturbed habitats. Mauritianus Pau & Sennen C. ladanifer subsp, C. palhinhae Ingram It is a popular ornamental plant, grown for its strongly resin-scented foliage and conspicuous flowers. Its leaves yield a fragrant oleoresin known as labdanum, used in perfumes and this plant has gained the Royal Horticultural Societys Award of Garden Merit. Jepson Manual Treatment Gum Rockrose page from Portugal USDA Plants Profile Photo gallery
2.
Opium
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Opium is the dried latex obtained from the opium poppy. The latex also contains the closely related opiates codeine and thebaine, the word meconium historically referred to related, weaker preparations made from other parts of the opium poppy or different species of poppies. The production of opium has not changed since ancient times, through selective breeding of the Papaver somniferum plant, the content of the phenanthrene alkaloids morphine, codeine, and to a lesser extent thebaine has been greatly increased. For the illegal trade, the morphine is extracted from the opium. It is then converted to heroin which is two to four times as potent, and increases the value by two to four times, the reduced weight and bulk make it easier to smuggle. Evidence from ancient Greece indicate that opium was consumed in several ways, including inhalation of vapors, suppositories, medical poultices, Opium is mentioned in the most important medical texts of the ancient world, including the Ebers Papyrus and the writings of Dioscorides, Galen, and Avicenna. Widespread medical use of unprocessed opium continued through the American Civil War before giving way to morphine and its successors, Opium has been actively collected since prehistoric times. Though western scholars typically estimate this to be around 1500 BCE, Indian scholars maintain that the verses and the history contained in them have been orally transmitted thousands of years before. A common name for males in Afghanistan is Redey, which in Pashto means poppy and this term may be derived from the Sanskrit words rddhi and hrdya, which mean magical, a type of medicinal plant, and heart-pleasing, respectively. The upper Asian belt of Afghanistan, Pakistan, northern India, numerous finds of P. somniferum or P. setigerum from Bronze Age and Iron Age settlements have also been reported. The first known cultivation of poppies was in Mesopotamia, approximately 3400 BCE, by Sumerians, who called the plant hul gil. Tablets found at Nippur, a Sumerian spiritual center south of Baghdad, described the collection of juice in the morning. Opium production continued under the Babylonians and Egyptians, Opium was used with poison hemlock to put people quickly and painlessly to death, but it was also used in medicine. The Ebers Papyrus, c. 1500 BCE, describes a way to stop a child using grains of the poppy plant strained to a pulp. Spongia somnifera, sponges soaked in opium, were used during surgery, the Egyptians cultivated opium thebaicum in famous poppy fields around 1300 BCE. Opium was traded from Egypt by the Phoenicians and Minoans to destinations around the Mediterranean Sea, including Greece, Carthage, and Europe. By 1100 BCE, opium was cultivated on Cyprus, where surgical-quality knives were used to score the poppy pods, and opium was cultivated, traded, Opium was also mentioned after the Persian conquest of Assyria and Babylonian lands in the 6th century BCE. From the earliest finds, opium has appeared to have ritual significance, and anthropologists have speculated ancient priests may have used the drug as a proof of healing power
3.
Analgesic
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An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. Analgesic drugs act in various ways on the peripheral and central nervous systems and they are distinct from anesthetics, which temporarily affect, and in some instances completely eliminate, sensation. Analgesics include paracetamol, the nonsteroidal anti-inflammatory drugs such as the salicylates, when choosing analgesics, the severity and response to other medication determines the choice of agent, the World Health Organization pain ladder specifies mild analgesics as its first step. Topical nonsteroidal anti-inflammatory drugs provided pain relief in common such as muscle sprains. Since the side effects are also lesser, topical preparations could be preferred over oral medications in these conditions, each different type of analgesic has its own associated side effects. Drugs for pain are typically classified by chemical structure and they may also be classified in other ways. Sometimes they are classified by use for classes of medical condition. Other times they are sorted by the needs of populations who would use them. They might be listed by availability in an area, perhaps to prevent recommending a drug which is illegal in one place even if it is easily available elsewhere. Paracetamol, also known as acetaminophen or APAP, is a used to treat pain. It is typically used for mild to moderate pain, in combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously, effects last between two and four hours. Paracetamol is classified as a mild analgesic, paracetamol is generally safe at recommended doses. Nonsteroidal anti-inflammatory drugs, are a class that groups together drugs that provide analgesic and antipyretic effects. The most prominent members of group of drugs, aspirin. These drugs have been derived from NSAIDs, the cyclooxygenase enzyme inhibited by NSAIDs was discovered to have at least 2 different versions, COX1 and COX2. Research suggested most of the effects of NSAIDs to be mediated by blocking the COX1 enzyme. Thus, the COX2 inhibitors were developed to inhibit only the COX2 enzyme and these drugs are equally effective analgesics when compared with NSAIDs, but cause less gastrointestinal hemorrhage in particular
4.
Ethanol
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Ethanol, also called alcohol, ethyl alcohol, and drinking alcohol, is the principal type of alcohol found in alcoholic beverages. It is a volatile, flammable, colorless liquid with a characteristic odor. Its chemical formula is C 2H 6O, which can be written also as CH 3-CH 2-OH or C 2H 5-OH, ethanol is mostly produced by the fermentation of sugars by yeasts, or by petrochemical processes. It is a psychoactive drug, causing a characteristic intoxication. It is widely used as a solvent, as fuel, and as a feedstock for synthesis of other chemicals, the eth- prefix and the qualifier ethyl in ethyl alcohol originally come from the name ethyl assigned in 1834 to the group C 2H 5- by Justus Liebig. He coined the word from the German name Aether of the compound C 2H 5-O-C 2H5, according to the Oxford English Dictionary, Ethyl is a contraction of the Ancient Greek αἰθήρ and the Greek word ύλη. The name ethanol was coined as a result of a resolution that was adopted at the International Conference on Chemical Nomenclature that was held in April 1892 in Geneva, Switzerland. The term alcohol now refers to a class of substances in chemistry nomenclature. The Oxford English Dictionary claims that it is a loan from Arabic al-kuḥl, a powdered ore of antimony used since aniquity as a cosmetic. The use of alcohol for ethanol is modern, first recorded 1753, the systematic use in chemistry dates to 1850. Ethanol is used in medical wipes and most common antibacterial hand sanitizer gels as an antiseptic, ethanol kills organisms by denaturing their proteins and dissolving their lipids and is effective against most bacteria and fungi, and many viruses. However, ethanol is ineffective against bacterial spores, ethanol may be administered as an antidote to methanol and ethylene glycol poisoning. Ethanol, often in high concentrations, is used to dissolve many water-insoluble medications, as a central nervous system depressant, ethanol is one of the most commonly consumed psychoactive drugs. The amount of ethanol in the body is typically quantified by blood alcohol content, small doses of ethanol, in general, produce euphoria and relaxation, people experiencing these symptoms tend to become talkative and less inhibited, and may exhibit poor judgment. Ethanol is commonly consumed as a drug, especially while socializing. The largest single use of ethanol is as a fuel and fuel additive. Brazil in particular relies heavily upon the use of ethanol as an engine fuel, gasoline sold in Brazil contains at least 25% anhydrous ethanol. Hydrous ethanol can be used as fuel in more than 90% of new gasoline fueled cars sold in the country, Brazilian ethanol is produced from sugar cane and noted for high carbon sequestration
5.
Tincture
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A tincture is typically an alcoholic extract of plant or animal material or solution of such, or of a low volatility substance. To qualify as a tincture, the extract should have an ethanol percentage of at least 25–60%. Sometimes an alcohol concentration as high as 90% is used in such a tincture, in herbal medicine, alcoholic tinctures are made with various ethanol concentrations, 25% being the most common. Herbal tinctures are not always made using ethanol as the solvent, other solvents include vinegar, glycerol, diethyl ether and propylene glycol, not all of which can be used for internal consumption. Ethanol has the advantage of being an excellent solvent for acidic and basic constituents. Glycerine can also be used, but when used in tincturing fashion is generally a poorer solvent, vinegar, being acidic, is a better solvent for obtaining alkaloids but a poorer solvent for acidic components. For individuals who choose not to ingest alcohol, non-alcoholic e, g. extracts offer an alternative for preparations meant to be taken internally. Some solutions of volatile or nonvolatile substances are called spirits, regardless of whether obtained by distillation or not. In chemistry, a tincture is a solution that has alcohol as its solvent, herbs are put in a container and a spirit of 40% or more ethanol is added, for example,80 proof vodka or 190 proof rectified spirit. The jar is left to stand for 2–3 weeks and shaken occasionally in order to maximize extraction, more accurate measuring can be done by combining 1 part herbs with a water-ethanol mixture of 2–10 parts, depending on the herb itself. For most tinctures, however,1 part water to 5 parts ethanol is typical, the concentrated, fuming, 35% acid is still sold under this name in the UK, for use as a drain-cleaning fluid. One can sometimes vary the proportion of ethanol and water to produce tinctures with different characteristics due to the solvent properties of these two. Tincture of calendula is commonly tinctured at either 25% or 90% ethanol, the alcohol content also acts as a preservative. It is widely employed as solvent for extraction. Ethanol has a tendency to denature some organic compounds, rendering them so changed as to be ineffective and this is one reason why ethanol is an antimicrobial. This tendency can also have undesirable effects when extracting botanical constituents, for instance, certain other constituents, common among them proteins, can become irreversibly denatured, or pickled in a manner of speaking. Also, extracted for highly complex aromatic components are denatured by alcohols intrinsic cleaving action upon a complex structure into simpler inert-rendered compounds. A basic tenet of organic chemistry teaches that any time a biologically viable component is denatured and this fact must be considered by the clinician and/or consumer from both the standpoint of efficacy and dosage when choosing ethanol-based botanical tinctures. Ether and propylene glycol based tinctures are not suitable for consumption, although they are used in preparations for external use, such as personal care cremes
6.
Mouth
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It is also the cavity lying at the upper end of the alimentary canal, bounded on the outside by the lips and inside by the pharynx and containing in higher vertebrates the tongue and teeth. This cavity is known as the buccal cavity, from the Latin bucca. Some animal phyla, including vertebrates, have a digestive system, with a mouth at one end. Which end forms first in ontogeny is a used to classify animals into protostome and deuterostome. In the first multicellular animals there was probably no mouth or gut, the particles became enclosed in vacuoles into which enzymes were secreted and digestion took place intracellularly. The digestive products were absorbed into the cytoplasm and diffused into other cells, the vast majority of other multicellular organisms have a mouth and a gut, the lining of which is continuous with the epithelial cells on the surface of the body. A few animals which live parasitically originally had guts but have secondarily lost these structures, the original gut of multicellular organisms probably consisted of a simple sac with a single opening, the mouth. Indigestible waste is ejected through the mouth, in animals at least as complex as an earthworm, the embryo forms a dent on one side, the blastopore, which deepens to become the archenteron, the first phase in the formation of the gut. In deuterostomes, the blastopore becomes the anus while the gut tunnels through to make another opening. In the protostomes, it used to be thought that the formed the mouth while the anus formed later as an opening made by the other end of the gut. More recent research, however, shows that in protostomes the edges of the slit-like blastopore close up in the middle, apart from sponges and placozoans, almost all animals have an internal gut cavity which is lined with gastrodermal cells. In less advanced invertebrates such as the sea anemone, the mouth also acts as an anus, circular muscles around the mouth are able to relax or contract in order to open or close it. A fringe of tentacles thrusts food into the cavity and it can gape widely enough to large prey items. Food passes first into a pharynx and digestion occurs extracellularly in the gastrovascular cavity, annelids have simple tube-like gets and the possession of an anus allows them to separate the digestion of their foodstuffs from the absorption of the nutrients. Many molluscs have a radula which is used to scrape microscopic particles off surfaces, in invertebrates with hard exoskeletons, various mouthparts may be involved in feeding behaviour. Insects have a range of mouthparts suited to their mode of feeding and these include mandibles, maxillae and labium and can be modified into suitable appendages for chewing, cutting, piercing, sponging and sucking. Decapods have six pairs of appendages, one pair of mandibles. Sea urchins have a set of five sharp calcareous plates which are used as jaws and are known as Aristotles lantern, in vertebrates, the first part of the digestive system is the buccal cavity, commonly known as the mouth
7.
Regulation of therapeutic goods
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The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. In some countries, such as the United States, they are regulated at the level by a single agency. In other jurisdictions they are regulated at the level, or at both state and national levels by various bodies, as is the case in Australia. The role of therapeutic goods regulation is designed mainly to protect the health, regulation is aimed at ensuring the safety, quality, and efficacy of the therapeutic goods which are covered under the scope of the regulation. In most jurisdictions, therapeutic goods must be registered before they are allowed to be marketed, there is usually some degree of restriction of the availability of certain therapeutic goods depending on their risk to consumers. Therapeutic goods in Australia are regulated by the Therapeutic Goods Administration, there are 5 main categories, Normal Medicines - Cough, cold and fever medicines, antiseptics, vitamins and others. Sold freely in pharmacies and some large supermarkets, red Stripe Medicines - These medicines are sold only with medical prescription. Antibiotics, Anti allergenics, Anti inflammatories, and other medicines, in Brazil, governmental control is loose on this type, it is not uncommon to buy this type of prescription medicine over the counter without a prescription. Red Stripe Psychoactive Medicines - These medicines are only with a Special Control white medical prescription with carbon copy. The original must be retained by the pharmacist after the sale, Drugs include anti-depressants, anti-convulsants, some sleep aids, anti-psychotics and other non-habit-inducing controlled medicines. Though some consider them habit inducing, anabolic steroids are also regulated under this category, black Stripe Medicines - These medicines are sold only with the Blue B Form medical prescription, which is valid for 30 days and must be retained by the pharmacist after the sale. Includes sedatives, some anorexic inducers and other habit-inducing controlled medicines, includes amphetamines and other stimulants, opioids and other strong habit-forming controlled medicines. In Canada, regulation of goods are governed by the Food and Drug Act. In addition, the Controlled Drugs and Substances Act requires additional regulatory requirements for controlled drugs, the regulation of drugs in Burma is governed by the Food and Drug Administration and Food and Drug Board of Authority. The regulation of drugs in China is governed by the China Food, Medicines for Human Use in the United Kingdom are regulated by the Medicines and Healthcare products Regulatory Agency. The availability of drugs is regulated by classification by the MHRA as part of marketing authorisation of a product, Medicines in the Republic of Ireland are regulated according to the Misuse of Drugs Regulations 1988. Controlled drugs are divided into five categories based on their potential for misuse, cD1, cannabis, lysergamide, coca leaf, etc. Use prohibited except in limited circumstances where a license has been granted, CD2, amphetamine, methadone, morphine, fentanyl, oxycodone, tapentadol, etc
8.
Controlled Substances Act
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The Controlled Substances Act is the statute establishing federal U. S. drug policy under which the manufacture, importation, possession, use and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, the Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs. The legislation created five Schedules, with varying qualifications for a substance to be included in each, classification decisions are required to be made on criteria including potential for abuse, currently accepted medical use in treatment in the United States, and international treaties. The nation first outlawed addictive drugs in the early 1900s and the International Opium Convention helped lead international agreements regulating trade, the Food and Drugs Act of 1906 was the beginning of over 200 laws concerning public health and consumer protections. Others were the Federal Food, Drug, and Cosmetic Act, in 1969, President Richard Nixon announced that the Attorney General, John N. Shafer—to study cannabis abuse in the United States. It implies an overwhelming indictment of the behavior which we believe is not appropriate, the actual and potential harm of use of the drug is not great enough to justify intrusion by the criminal law into private behavior, a step which our society takes only with the greatest reluctance. According to David T. Courtwright, the Act was part of a reform package designed to rationalize. It eliminated mandatory minimum sentences and provided support for drug treatment, king notes that the rehabilitation clauses were added as a compromise to Senator Jim Hughes, who favored a moderate approach. The bill, as introduced by Senator Everett Dirksen, ran to 91 pages, since its enactment in 1970, the Act has been amended several times, The Medical Device Amendments of 1976. The Psychotropic Substances Act of 1978 added provisions implementing the Convention on Psychotropic Substances, the Controlled Substances Penalties Amendments Act of 1984. The Ryan Haight Online Pharmacy Consumer Protection Act of 2008 The Electronic Prescriptions for Controlled Substances 2010, the Controlled Substances Act consists of 2 subchapters. Subchapter II describes the laws for exportation and importation of controlled substances, again specifying fines, the Drug Enforcement Administration was established in 1973, combining the Bureau of Narcotics and Dangerous Drugs and Customs drug agents. When a petition is received by the DEA, the agency begins its own investigation of the drug and this request is sent to the Assistant Secretary of Health of HHS. Under certain circumstances, the Government may temporarily schedule a drug without following the normal procedure, an example is when international treaties require control of a substance. In addition,21 U. S. C. §811 allows the Attorney General to temporarily place a substance in Schedule I to avoid an imminent hazard to the public safety, in any case, once these proceedings are complete, the temporary order is automatically vacated. Unlike ordinary scheduling proceedings, such orders are not subject to judicial review. The CSA also creates a system of distribution for those authorized to handle controlled substances. The cornerstone of this system is the registration of all those authorized by the DEA to handle controlled substances
9.
Single Convention on Narcotic Drugs
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Earlier treaties had only controlled opium, coca, and derivatives such as morphine, heroin and cocaine. The Single Convention, adopted in 1961, consolidated those treaties and broadened their scope to include cannabis, the Commission on Narcotic Drugs and the World Health Organization were empowered to add, remove, and transfer drugs among the treatys four schedules of controlled substances. The International Narcotics Control Board was put in charge of administering controls on production, international trade. As of February 2015, the Single Convention has 185 state parties. The Holy See plus all member states of the United Nations are state parties, with the exception of Chad, East Timor, Equatorial Guinea, Kiribati, Nauru, Samoa, South Sudan, Tuvalu, and Vanuatu. Since the Single Convention is not self-executing, Parties must pass laws to carry out its provisions, the Single Convention has been used as the basis for the standardization of national drug-control laws. In particular, the United States Controlled Substances Act of 1970, both Acts include analogous schemes of drug Scheduling, along with similar procedures for adding, removing, and transferring drugs among the Schedules. The Controlled Substances Act follows the Single Conventions lead in granting a public health authority a central role in drug-scheduling decisions and it also includes a provision mandating that federal authorities control all drugs of abuse in accordance with the strictness required by the Single Convention. The League of Nations adopted several drug control treaties prior to World War II, specifying uniform controls on addictive drugs such as cocaine and opium, and its derivatives. That year, the UN Economic and Social Council convened a conference of 73 nations for the adoption of a single convention on narcotic drugs. That meeting was known as the United Nations Conference on Narcotic Drugs and they were open to socio-cultural drug use, having lived with it for centuries. They favored weak controls because existing restrictions on production and export had directly affected large segments of their domestic population and they supported national control efforts based on local conditions and were wary of strong international control bodies under the UN. They also sought development aid to compensate for losses caused by strict controls and they favored strong supranational control bodies as long as they continued to exercise de facto control over such bodies. Strict control group, These were essentially non-producing and non-manufacturing states with no direct stake in the drug trade. The key members were France, Sweden, Brazil, and the Republic of China, most of the states in this group were culturally opposed to drug use and suffered from abuse problems. They favored restricting drug use to medical and scientific purposes and were willing to sacrifice a degree of sovereignty to ensure the effectiveness of supranational control bodies. They were forced to moderate their demands in order to secure the widest possible agreement, weak control group, This group was led by the Soviet Union and often included its allies in Europe, Asia and Africa. They considered drug control a purely internal issue and adamantly opposed any intrusion on national sovereignty, with little interest in the drug trade and minimal domestic abuse problems, they refused to give any supranational body excessive power, especially over internal decision-making
10.
Morphine
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Morphine is a pain medication of the opiate type which is found naturally in a number of plants and animals. It acts directly on the nervous system to decrease the feeling of pain. It can be taken for both pain and chronic pain. Morphine is frequently used for pain from myocardial infarction and during labour and it can be given by mouth, by injection into a muscle, by injecting under the skin, intravenously, into the space around the spinal cord, or rectally. Maximum effect is around 20 min when given intravenously and 60 min when given by mouth while duration of effect is three and seven hours. Potentially serious side effects include a decreased respiratory effort and low blood pressure, morphine has a high potential for addiction and abuse. If the dose is reduced after long-term use, withdrawal may occur, common side effects include drowsiness, vomiting, and constipation. Caution is advised when used during pregnancy or breast feeding, as morphine will affect the baby, morphine was first isolated between 1803 and 1805 by Friedrich Sertürner. This is generally believed to be the first isolation of an ingredient from a plant. Merck began marketing it commercially in 1827, morphine was more widely used after the invention of the hypodermic syringe in 1853–1855. Sertürner originally named the substance morphium after the Greek god of dreams, the primary source of morphine is isolation from poppy straw of the opium poppy. In 2013, an estimated 523,000 kilograms of morphine were produced, about 45,000 kilograms were used directly for pain, an increase over the last twenty years of four times. Most use for this purpose was in the developed world, about 70% of morphine is used to make other opioids such as hydromorphone, oxycodone and heroin. It is a Schedule II drug in the United States, Class A in the United Kingdom and it is on the World Health Organizations List of Essential Medicines, the most effective and safe medicines needed in a health system. Morphine is sold under trade names. Morphine is used primarily to treat both acute and chronic severe pain and it is also used for pain due to myocardial infarction and for labor pains. Its duration of analgesia is about three to seven hours, however, concerns exist that morphine may increase mortality in the setting of non ST elevation myocardial infarction. Morphine has also traditionally used in the treatment of acute pulmonary edema
11.
Opioid
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Opioids are substances that act on opioid receptors to produce morphine-like effects. Opioids are most often used medically to relieve pain, and by people addicted to opioids, opioids include opiates, an older term that refers to such drugs derived from opium, including morphine itself. Other opioids are semi-synthetic and synthetic drugs such as hydrocodone, oxycodone and fentanyl, antagonist drugs such as naloxone, the terms opiate and narcotic are sometimes encountered as synonyms for opioid. Opiate is properly limited to the alkaloids found in the resin of the opium poppy although some include semi-synthetic derivatives. In some jurisdictions all controlled drugs are classified as narcotics. The term can have pejorative connotations and its use is discouraged where that is the case. Primarily used for relief, including anesthesia they are also used to suppress cough, suppress diarrhea, treat addiction, reverse opioid overdose. Extremely strong opioids are approved only for use such as immobilizing large mammals. Opioids act by binding to receptors, which are found principally in the central and peripheral nervous system. These receptors mediate both the psychoactive and the effects of opioids. The side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, Tolerance and dependence will develop with continuous use, requiring increasing doses and leading to a withdrawal syndrome upon abrupt discontinuation. The euphoria attracts recreational use, and frequent, escalating recreational use of opioids typically results in addiction, accidental overdose or concurrent use with other depressant drugs commonly results in death from respiratory depression. Because of opioid drugs reputation for addiction and fatal overdose, most are controlled substances, illicit production, smuggling, and addiction to opioids prompted treaties, laws and policing which have realized limited success. In 2013 between 28 and 38 million people used opioids illicitly, in 2011 an estimated 4 million people in the United States used opioids recreationally or were dependent on them. Current increased rates of use and addiction are attributed to over-prescription of opioid medications. Conversely, fears about over-prescribing, exaggerated side effects and addiction from opioids are similarly blamed for under-treatment of pain, the term opioid originated in the 1950s. It combines opium + -oid meaning opiate-like, by the late 1960s, research found that opiate effects are mediated by activation of specific molecular receptors in the nervous system, which were termed opioid receptors. The definition of opioid was later refined to refer to substances that have activities that are mediated by the activation of opioid receptors
12.
Potency (pharmacology)
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In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity. A highly potent drug evokes a response at low concentrations. The potency depends on both the affinity and efficacy, affinity is the ability of the drug to bind to a receptor. Efficacy is the relationship between occupancy and the ability to initiate a response at the molecular, cellular, tissue or system level. The response is equal to the effect, or, and depends on both the binding and the drug-bound receptor then producing a response, thus, potency depends on both affinity and efficacy. The agonist, the ligand, drug or hormone that binds to the receptor, the Emax is the maximum possible effect for the agonist. The concentration of A at which E is 50% of Emax is termed the half maximal effective concentration and is abbreviated 50, the term potency refers to the 50 value. The lower the 50, the less the concentration of a drug is required to produce 50% of maximum effect, higher potency does not necessarily mean more side effects. Walker MG, Page CP, Hoffman BF, Curtis M
13.
Narcotic
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The term narcotic originally referred medically to any psychoactive compound with sleep-inducing properties. In the United States, it has become associated with opiates and opioids, commonly morphine and heroin. The primary three are morphine, codeine, and thebaine, legally speaking, the term narcotic is imprecisely defined and typically has negative connotations. When used in a context in the U. S. a narcotic drug is simply one that is totally prohibited, or one that is used in violation of governmental regulation. In the medical community, the term is more precisely defined, statutory classification of a drug as a narcotic often increases the penalties for violation of drug control statutes. The adoption of this Convention is regarded as a milestone in the history of drug law. The Convention also established the International Narcotics Control Board, merging the Permanent Central Board, the 1961 Convention seeks to control more than 116 drugs that it classifies as narcotic. These include, plant-based products such as opium and its derivatives morphine, codeine and heroin, synthetic narcotics such as methadone and pethidine, and cannabis, coca and cocaine. The Convention divides drugs into four groups, or schedules, in order to enforce a greater or lesser degree of control for the various substances, opium smoking and eating, coca leaf chewing, cannabis resin smoking and the non-medical use of cannabis are prohibited. In medicine, an agent that induces stupor, coma. In the context of drug control, “narcotic drug” means any drug defined as such under the 1961 Convention. In doing so, they approach the term from the law enforcement point of view, the best example is the definition of narcotics in the United Nations Conventions. Narcotics are substances and preparations that induce drowsiness, sleep, stupor, insensibility, etc. thus, the legal definition of a narcotic is whether or not it is listed on the Schedules of the Convention. If it is on some of the Schedules, it is narcotic, the term usually refers to opiates or opioids, which are called narcotic analgesics. In common parlance and legal usage, it is often used imprecisely to mean illicit drugs, for example, narcotics control legislation in Canada, USA, and certain other countries includes cocaine and cannabis as well as opioids. Because of this variation in usage, the term is best replaced by one with a specific meaning. Such term does not include the isoquinoline alkaloids of opium, poppy straw and concentrate of poppy straw. Coca leaves, except coca leaves and extracts of leaves from which cocaine, ecgonine
14.
Disease
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A disease is a particular abnormal condition, a disorder of a structure or function, that affects part or all of an organism. The study of disease is called pathology which includes the study of cause, Disease is often construed as a medical condition associated with specific symptoms and signs. When caused by pathogens, even in the literature, the term disease is often misleadingly used in the place of its causal agent. This language habitat can cause confusion in the communication of the principle in epidemiology. Diseases can affect not only physically, but also emotionally. Death due to disease is called death by natural causes, there are four main types of disease, infectious diseases, deficiency diseases, genetic diseases, and physiological diseases. Diseases can also be classified as communicable and non-communicable, the deadliest diseases in humans are coronary artery disease, followed by cerebrovascular disease and lower respiratory infections. In many cases, terms such as disease, disorder, morbidity, there are situations, however, when specific terms are considered preferable. Disease The term disease broadly refers to any condition that impairs the normal functioning of the body, for this reason, diseases are associated with dysfunctioning of the bodys normal homeostatic processes. The term disease has both a count sense and a noncount sense, by contrast, an infection that is asymptomatic during its incubation period, but expected to produce symptoms later, is usually considered a disease. Non-infectious diseases are all other diseases, including most forms of cancer, heart disease, acquired disease disease that began at some point during ones lifetime, as opposed to disease that was already present at birth, which is congenital disease. Acquired sounds like it could mean caught via contagion, but it simply means acquired sometime after birth and it also sounds like it could imply secondary disease, but acquired disease can be primary disease. It is often, genetic and can be inherited and it can also be the result of a vertically transmitted infection from the mother such as HIV/AIDS. Genetic disease disease that is caused by genetic mutation and it is often inherited, but some mutations are random and de novo. Hereditary or inherited disease a type of disease caused by mutation that is hereditary Iatrogenic disease A disease condition caused by medical intervention. Idiopathic disease disease whose cause is unknown, as medical science has advanced, many diseases whose causes were formerly complete mysteries have been somewhat explained or even extensively explained. Bacterial infections can be primary or secondary to a viral infection or burn. Terminal disease disease with death as an inevitable result Illness Illness is generally used as a synonym for disease, however, this term is occasionally used to refer specifically to the patients personal experience of his or her disease
15.
Antitussive
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Cough medicines are drugs used in those with coughing and related conditions. It is not known whether over-the-counter cough medications reduce coughing, There are a number of different cough and cold medications, which may be used for various coughing symptoms. Two examples are acetylcysteine and guaifenesin, antitussives, or cough suppressants, are substances which suppress the coughing itself. Examples are codeine, pholcodine, dextromethorphan, noscapine, and butamirate, antihistamines may produce mild sedation and reduce other associated symptoms, like a runny nose and watery eyes, one example is diphenhydramine. Antipyretics are substances that reduce fever, also employed are various substances supposed to soften the coughing, like honey or sugar syrup. There is no evidence supporting the effectiveness of over-the-counter cough medicines to reduce coughing. Some brand names include, Benilyn, Sudafed, Robitussin and Vicks among others, most contain a number of active ingredients. The efficacy of cough medication is questionable, particularly in children, a 2014 Cochrane review concluded that There is no good evidence for or against the effectiveness of OTC medicines in acute cough. Some cough medicines may be no more effective than placebos for acute coughs in adults, the American College of Chest Physicians emphasizes that cough medicines are not designed to treat whooping cough, a cough that is caused by bacteria and can last for months. No over-the-counter cough medicines have been found to be effective in cases of pneumonia and they are not recommended in those who have COPD or chronic bronchitis. There is not enough evidence to make recommendations for those who have a cough, dextromethorphan may be modestly effective in decreasing cough in adults with viral upper respiratory infections. However, in children it has not been found to be effective, codeine was once viewed as the gold standard in cough suppressants, but this position is now questioned. Some recent placebo-controlled trials have found that it may be no better than a placebo for some causes including acute cough in children and it is thus not recommended for children. Additionally, there is no evidence that hydrocodone is useful in children, similarly, a 2012 Dutch guideline regarding the treatment of acute cough does not recommend its use. A number of commercially available cough treatments have not been shown to be effective in viral upper respiratory infections. Long term diphenhydramine use is associated with negative outcomes in older people, honey may be a minimally effective cough treatment. A Cochrane review found the evidence to recommend for or against its use to be weak, in light of this they found it was better than no treatment, placebo, and diphenhydramine but not better than dextromethorphan for relieving cough symptoms. Honeys use as a treatment has been linked on several occasions to infantile botulism
16.
Medical prescription
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A prescription is a health-care program implemented by a physician or other qualified health care practitioner in the form of instructions that govern the plan of care for an individual patient. The term often refers to a health care providers written authorization for a patient to purchase a prescription drug from a pharmacist, Prescriptions may be entered into an electronic medical record system and transmitted electronically to a pharmacy. Alternatively, a prescription may be handwritten on preprinted prescription forms that have been assembled into pads, in some cases, a prescription may be transmitted from the physician to the pharmacist orally by telephone, this practice may increase the risk of medical error. The content of a prescription includes the name and address of the prescribing provider, unique for each prescription is the name of the patient. In the United Kingdom and Ireland, the name and address must also be recorded. Each prescription is dated and some jurisdictions may place a limit on the prescription. Prescriptions also contain directions for the patient to follow when taking the drug and these directions are printed on the label of the pharmaceutical product. ℞ is a symbol meaning prescription and it is sometimes transliterated as Rx or just Rx. This symbol originated in medieval manuscripts as an abbreviation of the Late Latin verb recipe, medieval prescriptions invariably began with the command to take certain materials and compound them in specified ways. Folk theories about the origin of the symbol ℞ note its similarity to the Eye of Horus, or to the ancient symbol for Zeus or Jupiter, gods whose protection may have been sought in medical contexts. The word prescription, from pre- and script, refers to the fact that the prescription is an order that must be written down before a drug can be prepared. Those within the industry will often call prescriptions simply scripts, jurisdictions may adopt a statutory definition of prescription that applies as a term of art only to the operation of that statute, but the general legal definition of the word is this broad one. Many brand name drugs have cheaper generic drug substitutes that are therapeutically and biochemically equivalent, Prescriptions will also contain instructions on whether the prescriber will allow the pharmacist to substitute a generic version of the drug. This instruction is communicated in a number of ways, in some jurisdictions, the preprinted prescription contains two signature lines, one line has dispense as written printed underneath, the other line has substitution permitted underneath. Some have a preprinted box dispense as written for the prescriber to check off, in other jurisdictions they may use completely different languages, never mind a different formula of words. In some jurisdictions, it may be a requirement to include the age of child on the prescription. For pediatric prescriptions some advise the inclusion of the age of the if the patient is less than twelve. Adding the weight of the child is also helpful, Prescriptions often have a label box
17.
Patent medicine
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A patent medicine, also known as a nostrum is a commercial product advertised as a purported over-the-counter medicine, without regard to its effectiveness. Sellers of liniments, claimed to contain oil and falsely promoted as a cure-all. Few if any of the nostrums were actually patented, chemical patents did not come into use in the United States until 1925, furthermore, patenting one of these remedies would have meant publicly disclosing its ingredients, which most promoters sought to avoid. Advertisement kept these patent medications in the eye and gave the belief that no disease was beyond the cure of patent medication. “The medicine man’s key task quickly became not production but sales, whether unscrupulous or self-deluded, nostrum makers set about this task with cleverness and zeal. ”Instead, the compounders of such nostrums used a primitive version of branding to distinguish their products from the crowd of their competitors. Though sold at high prices, many of products were made from cheap ingredients. Their composition was known within the pharmacy trade, and druggists manufactured. To protect profits, the branded medicine advertisements emphasized brand names, at least in the earliest days, the history of patent medicines is coextensive with scientific medicine. Empirical medicine, and the beginning of the application of the method to medicine. These few remedies, on the hand, were inadequate to cover the bewildering variety of diseases. This led medical men to hope, at least, that, say, given the state of the pharmacopoeia, and patients demands for something to take, physicians began making blunderbuss concoctions of various drugs, proven and unproven. These concoctions were the ancestors of the several nostrums, touting these nostrums was one of the first major projects of the advertising industry. The marketing of nostrums under implausible claims has a long history, within the English-speaking world, patent medicines are as old as journalism. Andersons Pills were first made in England in the 1630s, the recipe was allegedly learned in Venice by a Scot who claimed to be physician to King Charles I, daffys Elixir was invented about 1647 and remained popular in Britain and the USA until the late 19th century. The use of patent to obtain exclusive marketing rights to certain labelled formulas. The use of invented names began early, in 1726 a patent was also granted to the makers of Dr. Batemans Pectoral Drops, at least on the documents that survive, there was no Dr. Bateman. This was the enterprise of a Benjamin Okell and a group of promoters who owned a warehouse, perhaps the most successful industry that grew up out of the business of patent medicine advertisements, though, was founded by William H. Gannetts newspaper became the first publication of Guy Gannett Communications, which eventually owned four Maine dailies, muscle man acts were especially popular on these tours, for this enabled the salesman to tout the physical vigour the product supposedly offered
18.
Addiction
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Addiction is a brain disorder characterized by compulsive engagement in rewarding stimuli, despite adverse consequences. The two properties that characterize all addictive stimuli are that they are reinforcing and intrinsically rewarding, ΔFosB, a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions. Due to the relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, classic hallmarks of addiction include impaired control over substances or behavior, preoccupation with substance or behavior, and continued use despite consequences. Habits and patterns associated with addiction are typically characterized by immediate gratification, the only behavioral addiction recognized by the DSM-5 is gambling addiction. The term addiction is misused frequently to refer to other behaviors or disorders, particularly dependence. Addiction is the use of a substance or performance of a behavior that is independent of withdrawal. Cognitive control and stimulus control, which is associated with operant and classical conditioning, cognitive control, and particularly inhibitory control over behavior, is impaired in both addiction and attention deficit hyperactivity disorder. Stimulus-driven behavioral responses that are associated with a rewarding stimulus tend to dominate ones behavior in an addiction. The term behavioral addiction correctly refers to a compulsion to engage in a natural reward – which is a behavior that is inherently rewarding – despite adverse consequences, reviews of preclinical studies indicate that long-term frequent and excessive consumption of high fat or sugar foods can produce an addiction. Gambling is a natural reward which is associated with behavior and for which clinical diagnostic manuals. There is evidence from functional neuroimaging that gambling activates the reward system, similarly, shopping and playing videogames are associated with compulsive behaviors in humans and have also been shown to activate the mesolimbic pathway and other parts of the reward system. Based upon this evidence, gambling addiction, video game addiction, there are a range of genetic and environmental risk factors for developing an addiction that vary across the population. Roughly half of a risk for developing an addiction is derived from genetics. However, even in individuals with a low genetic loading. In other words, anyone can become an addict under the right circumstances, adolescence represents a period of unique vulnerability for developing addiction. Not only are more likely to initiate and maintain drug use. Statistics have shown that those who start to drink alcohol at a younger age are more likely to become dependent later on, about 33% of the population tasted their first alcohol between the ages of 15 and 17, while 18% experienced it prior to this
19.
Noscapine
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Noscapine is a benzylisoquinoline alkaloid from plants of the poppy family, without painkilling properties. This agent is used for its antitussive effects. Noscapine is often used as an antitussive medication, a 2012 Dutch guideline, however, does not recommend its use for coughing. Noscapine also has properties, inhibiting microtubule interactions, thereby stopping cell proliferation. The drug should not be taken with any MAOIs, as unknown, noscapine should not be taken in conjunction with warfarin as the anticoagulant effects of warfarin may be increased. Noscapines antitussive effects appear to be mediated by its σ–receptor agonist activity. Evidence for this mechanism is suggested by evidence in rats. Pretreatment with rimcazole, a σ-specific antagonist, causes a dose-dependent reduction in activity of noscapine. Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cell proliferation The lactone ring is unstable. The opposite reaction is presented in acidic media, the bond connecting the two optically active carbon atoms is also unstable. In aqueous solution of acid and heating it dissociates into cotarnine. When noscapine is reduced with zinc/HCl, the bond C1−C3′ saturates, noscapine was first isolated and characterized in chemical breakdown and properties in 1817 under the denomination of Narcotine by Pierre Robiquet, a French chemist in Paris. Many of the enzymes in the biosynthetic pathway was elucidated by the discovery of a 10 gene operon-like cluster named HN1. In 2016, the pathway of noscapine was reconstituted in yeast cells. Although produced at low yields, it is hoped this technology could be used in the future as a way of decreasing a drugs production cost, there are anecdotal reports of the recreational use of over-the-counter drugs in several countries, being readily available from local pharmacies without a prescription. The effects, beginning around 45 to 120 minutes after consumption, are similar to dextromethorphan, unlike dextromethorphan, noscapine is not an NMDA receptor antagonist. Noscapine can survive the manufacturing processes of heroin and can be found in street heroin and this is useful for law enforcement agencies, as the amounts of contaminants can identify the source of seized drugs. In 2005 in Liège, Belgium, the average concentration was around 8%
20.
United States
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Forty-eight of the fifty states and the federal district are contiguous and located in North America between Canada and Mexico. The state of Alaska is in the northwest corner of North America, bordered by Canada to the east, the state of Hawaii is an archipelago in the mid-Pacific Ocean. The U. S. territories are scattered about the Pacific Ocean, the geography, climate and wildlife of the country are extremely diverse. At 3.8 million square miles and with over 324 million people, the United States is the worlds third- or fourth-largest country by area, third-largest by land area. It is one of the worlds most ethnically diverse and multicultural nations, paleo-Indians migrated from Asia to the North American mainland at least 15,000 years ago. European colonization began in the 16th century, the United States emerged from 13 British colonies along the East Coast. Numerous disputes between Great Britain and the following the Seven Years War led to the American Revolution. On July 4,1776, during the course of the American Revolutionary War, the war ended in 1783 with recognition of the independence of the United States by Great Britain, representing the first successful war of independence against a European power. The current constitution was adopted in 1788, after the Articles of Confederation, the first ten amendments, collectively named the Bill of Rights, were ratified in 1791 and designed to guarantee many fundamental civil liberties. During the second half of the 19th century, the American Civil War led to the end of slavery in the country. By the end of century, the United States extended into the Pacific Ocean. The Spanish–American War and World War I confirmed the status as a global military power. The end of the Cold War and the dissolution of the Soviet Union in 1991 left the United States as the sole superpower. The U. S. is a member of the United Nations, World Bank, International Monetary Fund, Organization of American States. The United States is a developed country, with the worlds largest economy by nominal GDP. It ranks highly in several measures of performance, including average wage, human development, per capita GDP. While the U. S. economy is considered post-industrial, characterized by the dominance of services and knowledge economy, the United States is a prominent political and cultural force internationally, and a leader in scientific research and technological innovations. In 1507, the German cartographer Martin Waldseemüller produced a map on which he named the lands of the Western Hemisphere America after the Italian explorer and cartographer Amerigo Vespucci
21.
United Kingdom
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The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom or Britain, is a sovereign country in western Europe. Lying off the north-western coast of the European mainland, the United Kingdom includes the island of Great Britain, Northern Ireland is the only part of the United Kingdom that shares a land border with another sovereign state—the Republic of Ireland. The Irish Sea lies between Great Britain and Ireland, with an area of 242,500 square kilometres, the United Kingdom is the 78th-largest sovereign state in the world and the 11th-largest in Europe. It is also the 21st-most populous country, with an estimated 65.1 million inhabitants, together, this makes it the fourth-most densely populated country in the European Union. The United Kingdom is a monarchy with a parliamentary system of governance. The monarch is Queen Elizabeth II, who has reigned since 6 February 1952, other major urban areas in the United Kingdom include the regions of Birmingham, Leeds, Glasgow, Liverpool and Manchester. The United Kingdom consists of four countries—England, Scotland, Wales, the last three have devolved administrations, each with varying powers, based in their capitals, Edinburgh, Cardiff and Belfast, respectively. The relationships among the countries of the UK have changed over time, Wales was annexed by the Kingdom of England under the Laws in Wales Acts 1535 and 1542. A treaty between England and Scotland resulted in 1707 in a unified Kingdom of Great Britain, which merged in 1801 with the Kingdom of Ireland to form the United Kingdom of Great Britain and Ireland. Five-sixths of Ireland seceded from the UK in 1922, leaving the present formulation of the United Kingdom of Great Britain, there are fourteen British Overseas Territories. These are the remnants of the British Empire which, at its height in the 1920s, British influence can be observed in the language, culture and legal systems of many of its former colonies. The United Kingdom is a country and has the worlds fifth-largest economy by nominal GDP. The UK is considered to have an economy and is categorised as very high in the Human Development Index. It was the worlds first industrialised country and the worlds foremost power during the 19th, the UK remains a great power with considerable economic, cultural, military, scientific and political influence internationally. It is a nuclear weapons state and its military expenditure ranks fourth or fifth in the world. The UK has been a permanent member of the United Nations Security Council since its first session in 1946 and it has been a leading member state of the EU and its predecessor, the European Economic Community, since 1973. However, on 23 June 2016, a referendum on the UKs membership of the EU resulted in a decision to leave. The Acts of Union 1800 united the Kingdom of Great Britain, Scotland, Wales and Northern Ireland have devolved self-government
22.
Heroin
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Heroin, also known as diamorphine among other names, is an opiate typically used as a recreational drug for its euphoric effects. Medically it is used to relieve pain and as a form of opioid replacement therapy alongside counseling. Heroin is typically injected, usually into a vein, however, onset of effects is usually rapid and lasts for a few hours. Common side effects include respiratory depression and about a quarter of those who use heroin become physically dependent, other side effects can include abscesses, infected heart valves, blood borne infections, constipation, and pneumonia. After a history of use, withdrawal symptoms can begin within hours of last use. When given by injection into a vein, heroin has two to three times the effect as a dose of morphine. It typically comes as a white or brown powder, treatment of heroin addiction often includes behavioral therapy and medications. Medications used may include methadone or naltrexone, a heroin overdose may be treated with naloxone. An estimated 17 million people as of 2015 use opiates such as heroin, the total number of opiate users has increased from 1998 to 2007 after which it has remained more or less stable. In the United States about 1.6 percent of people have used heroin at some point in time, when people die from overdosing on a drug, the drug is usually an opioid. Heroin was first made by C. R. Alder Wright in 1874 from morphine, internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs. It is generally illegal to make, possess, or sell heroin without a license, in 2015 Afghanistan produced about 66% of the worlds opium. Often heroin, which is sold, is mixed with other substances such as sugar or strychnine. The original trade name of heroin is typically used in non-medical settings and it is used as a recreational drug for the euphoria it induces. Anthropologist Michael Agar once described heroin as the perfect whatever drug, tolerance develops quickly, and increased doses are needed in order to achieve the same effects. Its popularity with recreational users, compared to morphine, reportedly stems from its perceived different effects. In particular, users report an intense rush, an acute transcendent state of euphoria, while other opioids of recreational use produce only morphine, heroin also leaves 6-MAM, also a psycho-active metabolite. Equipotent injected doses had comparable action courses, with no difference in subjects self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, short-term addiction studies by the same researchers demonstrated that tolerance developed at a similar rate to both heroin and morphine
23.
Food and Drug Administration
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The Food and Drug Administration is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments. As of 2017, 3/4th of the FDA budget is funded by the pharmaceutical companies due to the Prescription drug user fee act and these include regulating lasers, cellular phones, condoms and control of disease on products ranging from certain household pets to sperm donation for assisted reproduction. The FDA is led by the Commissioner of Food and Drugs, appointed by the President with the advice, the Commissioner reports to the Secretary of Health and Human Services. Dr. Robert M. Califf, MD is the current commissioner, who took over in February 2016 for Dr. Stephen Ostroff, the FDA has its headquarters in unincorporated White Oak, Maryland. The agency also has 223 field offices and 13 laboratories located throughout the 50 states, the United States Virgin Islands, in 2008, the FDA began to post employees to foreign countries, including China, India, Costa Rica, Chile, Belgium, and the United Kingdom. The site was renamed from the White Oak Naval Surface Warfare Center to the Federal Research Center at White Oak, the first building, the Life Sciences Laboratory, was dedicated and opened with 104 employees on the campus in December 2003. Only one original building from the facility was kept. All other buildings are new construction, the project is slated to be completed by 2017, assuming future Congressional funding While most of the Centers are located in the Washington, D. C. The Office of Regulatory Affairs is considered the eyes and ears of the agency, the Office of Regulatory Affairs is divided into five regions, which are further divided into 20 districts. Districts are based roughly on the divisions of the federal court system. Each district comprises a main office and a number of Resident Posts. ORA also includes the Agencys network of laboratories, which analyze any physical samples taken. Though samples are usually food-related, some laboratories are equipped to analyze drugs, cosmetics, the Office of Criminal Investigations was established in 1991 to investigate criminal cases. Unlike ORA Investigators, OCI Special Agents are armed, and dont focus on aspects of the regulated industries. In many cases, OCI pursues cases involving Title 18 violations, OCI Special Agents often come from other criminal investigations backgrounds, and work closely with the Federal Bureau of Investigation, Assistant Attorney General, and even Interpol. OCI receives cases from a variety of sources—including ORA, local agencies, OCI is a smaller branch, comprising about 200 agents nationwide. The FDA frequently works with federal agencies, including the Department of Agriculture, Drug Enforcement Administration, Customs and Border Protection. Often local and state government agencies also work with the FDA to provide regulatory inspections, the FDA regulates more than US$1 trillion worth of consumer goods, about 25% of consumer expenditures in the United States
24.
Paregoric
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Paregoric, or camphorated tincture of opium, also known as tinctura opii camphorata, is a medication known for its antidiarrheal, antitussive, and analgesic properties. In the very early 18th century, Jakob Le Mort, a professor of chemistry at Leiden University, prepared an elixir for asthma and its ingredients were assembled out of the obsolete humoral philosophy and quasi-scientific reasoning of the Renaissance. Paregoric was used in formulations for hundreds of years. Dose--For children,5 to 20 drops, adults,1 to 2 teaspoons. The other, for Batemans Pectoral Drops, is, Opium in powder, catechu in powder, camphor gum, red saunders, rasped, the opium strength of this is about equal to paregoric, and it is used for similar purposes, and doses. During the 20th century its use declined as governments regulated its ingredients Beginning in late 2011, as of August 2012, however, the manufacture of paregoric has resumed. Previously many drugs had been sold as patent medicines with secret ingredients or misleading labels, cocaine, heroin, cannabis, and other such drugs continued to be legally available without prescription as long as they were labeled. It is estimated that sale of patent medicines containing opiates decreased by 33% after labeling was mandated, in 1906 in Britain and in 1908 in Canada laws requiring disclosure of ingredients and limitation of narcotic content were instituted. Paregoric was classified as an Exempt Narcotic, as were other medical products containing small amounts of opium or their derivatives, Tincture, Liquid No.338 was exactly 8 times the strength of Tincture Opium Camphorated, U. S. P. Designed for preparing the tincture by direct dilution, and cost $7 per pint, similarly, at a cost of $36 per pint, Opium Concentrated, for U. S. P. 336, was four times the strength of the official tincture, the catalog also noted, For quarter-pint bottles add 80c. per pint to the price given for pints. Until 1970, paregoric could be purchased in the United States at a pharmacy without a medical prescription, federal law dictated that no more than 2 ounces of paregoric be dispensed by any pharmacy to the same purchaser within a 48-hour period. Purchasers were also required to sign a register or logbook, some states further limited the sale of paregoric, or banned over-the-counter sales entirely. Even where legally permissible by law, OTC sale of paregoric was subject to the discretion of individual pharmacists and they were available over-the-counter without a prescription in many states until the early 1990s, at which time the FDA banned the sale of anti-diarrheal drugs containing kaolin and pectin. Paregoric is currently listed in the United States Pharmacopeia, in France, paregoric was available without prescription until 1986, nowadays, it is used to wean infants born to opiate-addicted women. The principal active ingredient in Paregoric is powdered opium, the average adult dose is 4 ml by mouth which corresponds to 16 mg of opium, or 1.6 mg of anhydrous morphine. It is unclear when the current formula for Paregoric, U. S. P. was developed in the United States, a slightly different formula is given in the 1926 pharmacoepia. The current formula for Paregoric, U. S. P. should not be assumed to be universal, Paregoric is sometimes confused with Laudanum, because their chemical names are similar, Camphorated Tincture of Opium vs. Tincture of Opium
25.
Synonym
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A synonym is a word or phrase that means exactly or nearly the same as another word or phrase in the same language. Words that are synonyms are said to be synonymous, and the state of being a synonym is called synonymy, the word comes from Ancient Greek sýn and ónoma. An example of synonyms are the words begin, start, commence, words can be synonymous when meant in certain senses, even if they are not synonymous in all of their senses. For example, if one talks about a time or an extended time, long. Some academics call the former type cognitive synonyms to distinguish them from the latter type, some lexicographers claim that no synonyms have exactly the same meaning because etymology, orthography, phonic qualities, ambiguous meanings, usage, etc. make them unique. Different words that are similar in meaning usually differ for a reason, feline is more formal than cat, long and extended are only synonyms in one usage, synonyms are also a source of euphemisms. In the figurative sense, two words are said to be synonymous if they have the same connotation. a widespread impression that. Metonymy can sometimes be a form of synonymy, as when, for example, thus a metonym is a type of synonym, and the word metonym is a hyponym of the word synonym. The analysis of synonymy, polysemy, hyponymy, and hypernymy is inherent to taxonomy and it has applications in pedagogy and machine learning, because they rely on word-sense disambiguation and schema. Synonyms can be any part of speech, as long as both words belong to the part of speech. Such like, he expired means the same as he died, in English, many synonyms emerged in the Middle Ages, after the Norman conquest of England. While Englands new ruling class spoke Norman French, the lower classes continued to speak Old English, thus, today we have synonyms like the Norman-derived people, liberty and archer, and the Saxon-derived folk, freedom and bowman. For more examples, see the list of Germanic and Latinate equivalents in English, the purpose of a thesaurus is to offer the user a listing of similar or related words, these are often, but not always, synonyms. The word poecilonym is a synonym of the word synonym. It is not entered in most major dictionaries and is a curiosity or piece of trivia for being a word because of its meta quality as a synonym of synonym. Antonyms are words with opposite or nearly opposite meanings, for example, hot ↔ cold, large ↔ small, thick ↔ thin, synonym ↔ antonym Hypernyms and hyponyms are words that refer to, respectively, a general category and a specific instance of that category. For example, vehicle is a hypernym of car, and car is a hyponym of vehicle, homophones are words that have the same pronunciation, but different meanings. For example, witch and which are homophones in most accents, homographs are words that have the same spelling, but have different pronunciations
26.
Paracelsus
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Paracelsus, born Philippus Aureolus Theophrastus Bombastus von Hohenheim, was a Swiss German philosopher, physician, botanist, astrologer, and general occultist. He is credited as the founder of toxicology and he is also a famous revolutionary for utilizing observations of nature, rather than referring to ancient texts, something of radical defiance during his time. He is credited for giving zinc its name, calling it zincum, modern psychology often also credits him for being the first to note that some diseases are rooted in psychological conditions. Paracelsus most important legacy is likely his critique of the methods in medicine, science. Much of his work does not withstand modern scientific thought. Paracelsus was born and raised in the village of Einsiedeln in Switzerland and his father, Wilhelm Bombast von Hohenheim, was a Swabian chemist and physician. His mother was Swiss and probably a bondswoman of the abbey of Einsiedeln in Switzerland where he was born, in 1502 the family moved to Villach, Carinthia where Paracelsus father worked as a physician, attending to the medical needs of the pilgrims and inhabitants of the cloister. Paracelsus was educated by his father in botany, medicine, mineralogy, mining and he also received a profound humanistic and theological education from local clerics and the convent school of St. Pauls Abbey in the Lavanttal. He specifically accounts for being tutored by Johannes Trithemius, abbot of Sponheim, at the age of 16 he started studying medicine at the University of Basel, later moving to Vienna. He gained his degree from the University of Ferrara in 1515 or 1516. He was employed as a surgeon in the Venetian service in 1522. His wanderings as an itinerant physician and sometime journeyman miner took him through Germany, France, Spain, Hungary, Paracelsus was well known as a difficult man. He gained a reputation for being arrogant and soon garnered the anger of other physicians in Europe, some even claim he was a habitual drinker. He was prone to outbursts of abusive language, abhorred untested theory. He held the chair of medicine at the University of Basel and he angered his colleagues by lecturing in German instead of Latin in order to make medical knowledge more accessible to the common people. He is credited as the first to do so and he was the first to publicly condemn the medical authority of Avicenna and Galen and threw their writings into a bonfire on St. Johns Day in 1527. In 1526 he bought the rights of citizenship in Strasbourg to establish his own practice, but soon after he was called to Basel to the sickbed of Johann Froben or Frobenius, a successful printer and publisher. Based on historical accounts, Paracelsus cured Frobenius and he was a contemporary of Copernicus, Leonardo da Vinci and Martin Luther
27.
Swiss people
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The Swiss are citizens of Switzerland. The demonym derives from the toponym of Schwyz and has been in use to refer to the Old Swiss Confederacy since the 16th century. The number of Swiss nationals has grown from 1.7 million in 1815 to 6.76 million in 2009 with 90% of them living in Switzerland, about 60% of those living abroad reside in the European Union. The largest groups of Swiss descendants and nationals outside of Europe are found in the United States, closely related German-speaking peoples are the Alsatians, the Swabians and the Vorarlbergians. The French-speaking Swiss, traditionally speaking Franco-Provençal dialects, today largely assimilated to the standard French language, amalgamated from the Gallo-Roman population and they are closely related to the French. The Italian-speaking Swiss, traditionally speakers of Lombard language today partly assimilated to the standard Italian language, amalgamated from Raetians and they are closely related to the Italians. The Romansh, speakers of the Romansh language, settling in parts of the Grisons, with worldwide human migration, there are an increasing number of Swiss not descended or only partially descended from the core ethnic groups listed above. Most naturalized Swiss citizens will be linguistically oriented according to their canton of residence, the Swiss populace historically derives from an amalgamation of Gaulish or Gallo-Roman, Alamannic and Rhaetic stock. Their cultural history is dominated by the Alps, and the environment is often cited as an important factor in the formation of the Swiss national character. Political allegiance and patriotism was directed towards the cantons, not the federal level, from the 19th century there were conscious attempts to foster a federal Pan-Swiss national identity that would replace or alleviate the cantonal patriotisms. An additional symbol of national identity at the federal level was introduced with the Swiss national holiday in 1889. The bonfires associated with the holiday have become so customary since then that they have displaced the Funken traditions of greater antiquity. These specifically include Grisons, Valais, Ticino, Vaud and Geneva, according to Hartley-Moore, Localized equivalents of nationalist symbols were also essential to the creation of Swiss civil society. In the Swiss model, pride in local identity is to some degree synonymous with loyalty to the larger state, as Gottfried Keller argued in the nineteenth century, Without cantons and without their differences and competition, no Swiss federation could exist. Facilitated naturalization for foreign spouses and children of Swiss citizens requires a total minimum residence of five years, with more than 20% of the population resident aliens, Switzerland has one of the highest ratios of non-naturalized inhabitants in Europe. In 2003,35,424 residents were naturalized, a number exceeding net population growth. Over the 25-year period of 1983 to 2007,479,264 resident foreigners were naturalized, compare the figure of 0. 2% in the United Kingdom. The genetic composition of the Swiss population is similar to that of Central Europe in general, Switzerland is on one hand at the crossroads of several prehistoric migrations, while on the other hand the Alps acted as a refuge in some cases
28.
Alchemy
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Alchemy is a philosophical and protoscientific tradition practiced throughout Europe, Egypt and Asia. It aimed to purify, mature, and perfect certain objects, the perfection of the human body and soul was thought to permit or result from the alchemical magnum opus and, in the Hellenistic and western tradition, the achievement of gnosis. In Europe, the creation of a stone was variously connected with all of these projects. In English, the term is limited to descriptions of European alchemy, but similar practices existed in the Far East, the Indian subcontinent. In Europe, following the 12th-century Renaissance produced by the translation of Islamic works on science, Islamic and European alchemists developed a structure of basic laboratory techniques, theory, terminology, and experimental method, some of which are still in use today. However, they continued antiquitys belief in four elements and guarded their work in secrecy including cyphers and their work was guided by Hermetic principles related to magic, mythology, and religion. The latter interests historians of esotericism, psychologists, and some philosophers, the subject has also made an ongoing impact on literature and the arts. The word alchemy was borrowed from Old French alquemie, alkimie, taken from Medieval Latin alchymia, the Arabic word is borrowed from Late Greek chēmeía, chēmía, with the agglutination of the Arabic definite article al-. This ancient Greek word was derived from the early Greek name for Egypt, Chēmia, based on the Egyptian name for Egypt, the Medieval Latin form was influenced by Greek chymeia meaning ‘mixture’ and referring to pharmaceutical chemistry. Alchemy covers several philosophical traditions spanning some four millennia and three continents and these traditions general penchant for cryptic and symbolic language makes it hard to trace their mutual influences and genetic relationships. It is still a question whether these three strands share a common origin, or to what extent they influenced each other. Here, elements of technology, religion, mythology, and Hellenistic philosophy, each with their own much longer histories, Zosimos of Panopolis wrote the oldest known books on alchemy, while Mary the Jewess is credited as being the first non-fictitious Western alchemist. They wrote in Greek and lived in Egypt under Roman rule, mythology – Zosimos of Panopolis asserted that alchemy dated back to Pharaonic Egypt where it was the domain of the priestly class, though there is little to no evidence for his assertion. Alchemical writers used Classical figures from Greek, Roman, and Egyptian mythology to illuminate their works and these included the pantheon of gods related to the Classical planets, Isis, Osiris, Jason, and many others. The central figure in the mythology of alchemy is Hermes Trismegistus and his name is derived from the god Thoth and his Greek counterpart Hermes. Hermes and his caduceus or serpent-staff, were among alchemys principal symbols, according to Clement of Alexandria, he wrote what were called the forty-two books of Hermes, covering all fields of knowledge. The Hermetica of Thrice-Great Hermes is generally understood to form the basis for Western alchemical philosophy and practice and these writings were collected in the first centuries of the common era. Technology – The dawn of Western alchemy is sometimes associated with that of metallurgy, Many writings were lost when the emperor Diocletian ordered the burning of alchemical books after suppressing a revolt in Alexandria
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Latin
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Latin is a classical language belonging to the Italic branch of the Indo-European languages. The Latin alphabet is derived from the Etruscan and Greek alphabets, Latin was originally spoken in Latium, in the Italian Peninsula. Through the power of the Roman Republic, it became the dominant language, Vulgar Latin developed into the Romance languages, such as Italian, Portuguese, Spanish, French, and Romanian. Latin, Italian and French have contributed many words to the English language, Latin and Ancient Greek roots are used in theology, biology, and medicine. By the late Roman Republic, Old Latin had been standardised into Classical Latin, Vulgar Latin was the colloquial form spoken during the same time and attested in inscriptions and the works of comic playwrights like Plautus and Terence. Late Latin is the language from the 3rd century. Later, Early Modern Latin and Modern Latin evolved, Latin was used as the language of international communication, scholarship, and science until well into the 18th century, when it began to be supplanted by vernaculars. Ecclesiastical Latin remains the language of the Holy See and the Roman Rite of the Catholic Church. Today, many students, scholars and members of the Catholic clergy speak Latin fluently and it is taught in primary, secondary and postsecondary educational institutions around the world. The language has been passed down through various forms, some inscriptions have been published in an internationally agreed, monumental, multivolume series, the Corpus Inscriptionum Latinarum. Authors and publishers vary, but the format is about the same, volumes detailing inscriptions with a critical apparatus stating the provenance, the reading and interpretation of these inscriptions is the subject matter of the field of epigraphy. The works of several hundred ancient authors who wrote in Latin have survived in whole or in part and they are in part the subject matter of the field of classics. The Cat in the Hat, and a book of fairy tales, additional resources include phrasebooks and resources for rendering everyday phrases and concepts into Latin, such as Meissners Latin Phrasebook. The Latin influence in English has been significant at all stages of its insular development. From the 16th to the 18th centuries, English writers cobbled together huge numbers of new words from Latin and Greek words, dubbed inkhorn terms, as if they had spilled from a pot of ink. Many of these words were used once by the author and then forgotten, many of the most common polysyllabic English words are of Latin origin through the medium of Old French. Romance words make respectively 59%, 20% and 14% of English, German and those figures can rise dramatically when only non-compound and non-derived words are included. Accordingly, Romance words make roughly 35% of the vocabulary of Dutch, Roman engineering had the same effect on scientific terminology as a whole
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Pearl
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A pearl is a hard object produced within the soft tissue of a living shelled mollusk or another animal, such as a conulariid. Just like the shell of a clam, a pearl is composed of calcium carbonate. in minute crystalline form, the ideal pearl is perfectly round and smooth, but many other shapes, known as baroque pearls, can occur. The finest quality natural pearls have been valued as gemstones. Because of this, pearl has become a metaphor for something rare, fine, the most valuable pearls occur spontaneously in the wild, but are extremely rare. These wild pearls are referred to as natural pearls, cultured or farmed pearls from pearl oysters and freshwater mussels make up the majority of those currently sold. Imitation pearls are widely sold in inexpensive jewelry, but the quality of their iridescence is usually very poor and is easily distinguished from that of genuine pearls. Pearls have been harvested and cultivated primarily for use in jewelry and they have also been crushed and used in cosmetics, medicines and paint formulations. Whether wild or cultured, gem-quality pearls are almost always nacreous and iridescent, however, almost all species of shelled mollusks are capable of producing pearls of lesser shine or less spherical shape. The English word pearl comes from the French perle, originally from the Latin perna meaning leg, nacreous pearls, the best-known and most commercially significant, are primarily produced by two groups of molluskan bivalves or clams. A nacreous pearl is made from layers of nacre, by the same living process as is used in the secretion of the mother of pearl which lines the shell, natural pearls, formed without human intervention, are very rare. Cultured pearls are formed in pearl farms, using human intervention as well as natural processes, saltwater pearls can grow in several species of marine pearl oysters in the family Pteriidae. Freshwater pearls grow within certain species of mussels in the order Unionida. The unique luster of pearls depends upon the reflection, refraction, the thinner and more numerous the layers in the pearl, the finer the luster. The iridescence that pearls display is caused by the overlapping of successive layers, in addition, pearls can be dyed yellow, green, blue, brown, pink, purple, or black. The very best pearls have a metallic mirror-like luster, because pearls are made primarily of calcium carbonate, they can be dissolved in vinegar. Calcium carbonate is susceptible to even a weak acid solution because the crystals of calcium carbonate react with the acid in the vinegar to form calcium acetate. Freshwater and saltwater pearls may sometimes look quite similar, but they come from different sources, Freshwater pearls form in various species of freshwater mussels, family Unionidae, which live in lakes, rivers, ponds and other bodies of fresh water. These freshwater pearl mussels occur not only in hotter climates, most freshwater cultured pearls sold today come from China
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Musk
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Musk is a class of aromatic substances commonly used as base notes in perfumery. They include glandular secretions from animals such as the deer, numerous plants emitting similar fragrances. Musk was a name given to a substance with a penetrating odor obtained from a gland of the male musk deer. The substance has been used as a perfume fixative since ancient times and is one of the most expensive animal products in the world. The name originates from the Late Greek μόσχος moskhos, from Persian mushk, from Sanskrit muska-s testicle, the deer gland was thought to resemble a scrotum. Applied to various plants and animals of similar smell and has come to encompass a variety of aromatic substances with similar odors. Until the late 19th century, natural musk was used extensively in perfumery until economic and ethical motives led to the adoption of synthetic musk, the organic compound primarily responsible for the characteristic odor of musk is muscone. Modern use of natural musk pods occurs in traditional Chinese medicine, the musk deer belongs to the family Moschidae and lives in Nepal, Tibet, India, Pakistan, China, Siberia and Mongolia. The musk pod is normally obtained by killing the male deer through traps laid in the wild, upon drying, the reddish-brown paste inside the musk pod turns into a black granular material called musk grain, which is then tinctured with alcohol. The aroma of the tincture gives a pleasant odor only after it is considerably diluted, Musk has been a key constituent in many perfumes since its discovery, being held to give a perfume long-lasting power as a fixative. Today, the quantity of the natural musk is controlled by CITES. Muskrat, a rodent native to North America, has known since the 17th century to secrete a glandular substance with a musky odor. A chemical means of extracting it was discovered in the 1940s, in crocodiles, there are two pairs of musk glands, one pair situated at the corner of the jaw and the other pair in the cloaca. Musk glands are found in snakes. Some plants such as Angelica archangelica or Abelmoschus moschatus produce musky-smelling macrocyclic lactone compounds and these compounds are widely used in perfumery as substitutes for animal musk or to alter the smell of a mixture of other musks. The plant sources include the flower of western North America, the muskwood of Australia. Since obtaining the deer musk requires killing the animal, nearly all musk fragrance used in perfumery today is synthetic. They can be divided into three classes, aromatic nitro musks, polycyclic musk compounds, and macrocyclic musk compounds
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Amber
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Amber is fossilized tree resin, which has been appreciated for its color and natural beauty since Neolithic times. Much valued from antiquity to the present as a gemstone, amber is made into a variety of decorative objects and it has also been used as a healing agent in folk medicine. There are five classes of amber, defined on the basis of their chemical constituents, because it originates as a soft, sticky tree resin, amber sometimes contains animal and plant material as inclusions. Amber occurring in coal seams is also called resinite, and the term ambrite is applied to that found specifically within New Zealand coal seams, the English word amber derives from Arabic ʿanbar عنبر via Middle Latin ambar and Middle French ambre. The word was adopted in Middle English in the 14th century as referring to what is now known as ambergris, in the Romance languages, the sense of the word had come to be extended to Baltic amber from as early as the late 13th century. At first called white or yellow amber, this meaning was adopted in English by the early 15th century, as the use of ambergris waned, this became the main sense of the word. The two substances conceivably became associated or confused because they both were washed up on beaches. Ambergris is less dense water and floats, whereas amber is too dense to float. The classical names for amber, Latin electrum and Ancient Greek ἤλεκτρον, are connected to a term ἠλέκτωρ meaning beaming Sun, according to myth, when Phaëton son of Helios was killed, his mourning sisters became poplar trees, and their tears became elektron, amber. Earlier Pliny says that an island of three days sail from the Scythian coast called Balcia by Xenophon of Lampsacus, author of a fanciful travel book in Greek, is called Basilia by Pytheas. It is generally understood to be the same as Abalus and it is assumed that there were well-established trade routes for amber connecting the Baltic with the Mediterranean. Pliny states explicitly that the Germans export amber to Pannonia, from where it was traded further abroad by the Veneti, the ancient Italic peoples of southern Italy were working amber, the most important examples are on display at the National Archaeological Museum of Siritide to Matera. Amber used in antiquity as at Mycenae and in the prehistory of the Mediterranean comes from deposits of Sicily. Besides the fanciful explanations according to which amber is produced by the Sun, Pliny cites opinions that are aware of its origin in tree resin. Amber is produced from a marrow discharged by trees belonging to the genus, like gum from the cherry. This is confirmed by the recorded Old High German glas and Old English glær for amber, in Middle Low German, amber was known as berne-, barn-, börnstēn. The Low German term became dominant also in High German by the 18th century, the Baltic Lithuanian term for amber is gintaras and Latvian dzintars. They, and the Slavic jantar or Hungarian gyanta, are thought to originate from Phoenician jainitar, Early in the nineteenth century, the first reports of amber from North America came from discoveries in New Jersey along Crosswicks Creek near Trenton, at Camden, and near Woodbury
