Lawrence County is the southernmost county of the U.S. state of Ohio. As of the 2020 census, the population was 58,240. Its county seat is Ironton. The county was created in 1815 and later organized in 1817. It is named for James Lawrence, the naval officer famous for the line "do not give up the ship". Lawrence County is part of the Huntington–Ashland metropolitan area.

Ironton is a city in and the county seat of Lawrence County, Ohio, United States.The population was 10,571 at the 2020 census. Located in southernmost Ohio along the Ohio River, it is 20 miles (32 km) northwest of Huntington, West Virginia, within the Huntington–Ashland metropolitan area. The city's name is a contraction of "iron town", stemming from its long ties to the iron industry. It also had one of the first professional football teams, the Ironton Tanks.