Laytonsville is a town in Montgomery County, Maryland, United States. The population was 572 at the 2020 census, up from 353 in 2010. Laytonsville was incorporated in 1892.

Maryland Route 108 is a state highway in the U.S. state of Maryland. The highway runs 34.23 miles (55.09 km) from MD 27 in Damascus east to MD 175 in Columbia. MD 108 is an S-shaped highway that winds through northern Montgomery County and central Howard County. The highway connects the Montgomery County communities of Laytonsville, Olney, Sandy Spring, and Ashton with the Howard County villages of Highland and Clarksville. MD 108 serves as the northern edge of Columbia and connects several of the planned community's suburban villages.