Le Martyre de saint Sébastien is a five-act musical mystery play on the subject of Saint Sebastian, with a text written in 1911 by the Italian author Gabriele D'Annunzio and incidental music by the French composer Claude Debussy (L.124).

Sebastian was an early Christian saint and martyr. According to traditional belief, he was killed during the Diocletianic Persecution of Christians. He was initially tied to a post or tree and shot with arrows, though this did not kill him. He was, according to tradition, rescued and healed by Irene of Rome, which became a popular subject in 17th-century painting. In all versions of the story, shortly after his recovery he went to Diocletian to warn him about his sins, and as a result was clubbed to death. He is venerated in the Catholic Church and the Orthodox Church.