Lead(II) oxide, also called lead monoxide, is the inorganic compound with the molecular formula PbO. PbO occurs in two polymorphs: litharge having a tetragonal crystal structure, and massicot having an orthorhombic crystal structure. Modern applications for PbO are mostly in lead-based industrial glass and industrial ceramics, including computer components. It is an amphoteric oxide.

Lead glass, commonly called crystal, is a variety of glass in which lead replaces the calcium content of a typical potash glass. Lead glass contains typically 18–40% lead(II) oxide (PbO), while modern lead crystal, historically also known as flint glass due to the original silica source, contains a minimum of 24% PbO. Lead glass is often desirable for a variety of uses due to its clarity. In marketing terms it is often called crystal glass.