Leake County is a county in the center of the U.S. state of Mississippi. As of the 2020 census, the population was 21,275. Its county seat is Carthage. The county is named for Walter Leake, the Governor of Mississippi from 1822 to 1825.

The city of Carthage is the county seat of Leake County, Mississippi, United States. The population was 5,075 at the 2010 census.