Lee County is a county located in the U.S. state of Arkansas. With its eastern border formed by the Mississippi River, it is considered to be part of the Arkansas Delta. As of the 2020 census, the population was 8,600. The county seat is Marianna.

Highway 1 is a north–south state highway in east Arkansas. The route of 159.88 miles (257.30 km) runs from US Route 278 (US 278) in McGehee north to Supplemental Route BB at the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately 50 miles (80 km) with U.S. Route 49.