Leflore County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 28,339. The county seat is Greenwood. The county is named for Choctaw leader Greenwood LeFlore, who signed a treaty to cede his people's land to the United States in exchange for land in Indian Territory. LeFlore stayed in Mississippi, settling on land reserved for him in Tallahatchie County.

Greenwood is a city in and the county seat of Leflore County, Mississippi, United States, located at the eastern edge of the Mississippi Delta region, approximately 96 miles north of the state capital, Jackson, and 130 miles south of the riverport of Memphis, Tennessee. It was a center of cotton planter culture in the 19th century.