Leighton is a town in Colbert County, Alabama, United States. It is part of the Florence - Muscle Shoals Metropolitan Statistical Area known as "The Shoals". At the 2020 census, the population was 665. Leighton has been hit by several tornadoes in the 2000s, including a damaging EF2 on May 8, 2008, that was caught on tape flipping over many cars and damaging buildings.

Colbert County is a county located in the northwestern part of the U.S. state of Alabama. As of the 2020 census the county's population was 57,227. The county seat is Tuscumbia. The largest city is Muscle Shoals.