Leinefelde-Worbis is a town in the district of Eichsfeld, in northwestern Thuringia, Germany. The town was formed on March 16, 2004, from the former independent towns Leinefelde and Worbis along with the municipalities of Breitenbach and Wintzingerode. In July 2018 the former municipality of Hundeshagen, and in January 2019 Kallmerode was merged into Leinefelde-Worbis. The population before the amalgamation was 14,387 for Leinefelde, 5,541 for Worbis, 1,021 for Breitenbach and 614 for Wintzingerode. The 10 parts of Leinefelde-Worbis are Leinefelde, Worbis, Breitenbach, Kirchohmfeld, Birkungen, Beuren, Hundeshagen, Kaltohmfeld, Wintzingrode, Kallmerode and Breitenholz.

Leinefelde station is a major railway junction in the German state of Thuringia and is the most important station in Eichsfeld. It is located in the town of Leinefelde in the Thuringian municipality of Leinefelde-Worbis in the Eichsfeld district. The Halle–Kassel and Gotha–Leinefelde railways meet there and in the past the now closed Leinefelde–Wulften and Leinefelde–Treysa railways also connected with the station. The latter route was part of the Kanonenbahn between Berlin and Metz.