Leland is a city in Washington County, Mississippi, United States. It is located within the Mississippi Delta, on the banks of Deer Creek. The population was 4,481 at the 2010 census. It was once a railway town and had long been a center of cotton culture, which is still an important commodity crop in the rural area. It was once considered the second-largest city in Washington County in 1920 due to its rapid growth of residents, businesses, and schools.

U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage, then continued to Thunder Bay, Canada, as Ontario Highway 61. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.