Letterkenny Army Depot, the Center of Industrial and Technical Excellence (CITE) for Air Defense and Tactical Missile Systems, was established in early 1942. Its leadership began recruiting civilian personnel in July 1942.

The United States Army Aviation and Missile Command (AMCOM) develops, acquires, fields and sustains aviation, missile and unmanned aerial vehicles. AMCOM is primarily responsible for lifecycle management of army missile, helicopter, unmanned ground vehicle and unmanned aerial vehicle weapon system. The central part of AMCOM's mission involves ensuring readiness through acquisition and sustainment support for aviation systems, missile systems, and test, measurement, and diagnostic equipment (TMDE) throughout their life cycle. The command is headquartered at Redstone Arsenal in Huntsville, Alabama, has a 2019 "budget of more $3.7 billion, and a global workforce of more than 15,000 military and civilian employees".