Levice District is a district in the Nitra Region of western Slovakia. It is the largest of Slovakia's 79 districts. The west of the district was in the Hungarian county of Bars until 1918, while the east of the district was in Hont County: Farná in the south was in the county of Esztergom (Ostrihom).

The Nitra Region is one of the administrative regions of Slovakia. It was first established in 1923 and from 1996 exists in its present borders. It consists of seven districts and 354 municipalities, from which 16 have a town status. The economy of the region focuses more on agriculture, than in other Slovak regions. Nitra is its seat, largest city, and cultural and economic center.