Lewis County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 17,033. Its county seat is Weston. The county was formed in 1816 from Harrison County.

Weston is a city in and the county seat of Lewis County, West Virginia, United States. The population was 3,943 at the 2020 census. It is home to the Museum of American Glass in West Virginia and the Trans-Allegheny Lunatic Asylum.