Lewis and Clark High School is a four-year public secondary school in Spokane, Washington, United States. Opened in 1912, it is located at 521 W. Fourth Ave. in the Cliff/Cannon neighborhood of downtown Spokane, bounded by I-90 to the north and MultiCare Deaconess Hospital to the west. It replaced South Central High School, destroyed by fire in 1910, and was named for the two leaders of the Corps of Discovery.

Cliff/Cannon is a neighborhood in Spokane, Washington. It is located immediately south of Downtown, Spokane, and on the lower reaches of the broader South Hill. The neighborhood is home to a medical district with Sacred Heart and Deaconess both having their main hospital campuses along Cliff/Cannon's denser northern edge. To the south the neighborhood becomes more residential. City parks break up the residential zoning of the southern half of Cliff/Cannon. It is adjacent to the Cannon Hill area of the neighboring but separate Manito/Cannon Hill neighborhood. The Marycliff-Cliff Park Historic District, a National Historic District listed on the National Register of Historic Places, is located within the neighborhood.