Lewisberry is a borough in York County, Pennsylvania, United States. The population was 380 at the 2020 census. It is part of the York–Hanover metropolitan area.

Pennsylvania Route 382 is an 11.8-mile-long (19.0 km) state highway located in York County, Pennsylvania. The southern terminus is at PA 181 in York Haven. The western terminus is at PA 114 near Bunches in Fairview Township. PA 382 is a two-lane undivided road that runs through rural areas in the northern part of York County. The route heads west from York Haven, intersecting PA 262 and PA 297. Farther west, the road has an interchange with Interstate 83 (I-83) in Newberrytown and an intersection with PA 177 in Lewisberry. From here, PA 382 turns north and continues to its terminus at PA 114. What is now PA 382 was designated as a portion of PA 24 in 1928. PA 382 was designated to its current alignment in 1961 after the northern terminus of PA 24 was truncated to the York area.