Lewistown station is an Amtrak railway station located about 60 miles northwest of Harrisburg, Pennsylvania at PA 103 and Helen Street in Lewistown, Mifflin County, Pennsylvania. The station is actually located across the Juniata River from Lewistown proper, a little less than one mile south of the center of the borough. It is currently only served by Amtrak's Pennsylvanian, which operates once per day in each direction, though until 2005, Lewistown was served by a second daily train, the Three Rivers, an extended version of the Pennsylvanian that terminated in Chicago. Upon its cancellation, the sole Pennsylvanian marked the first time in Lewistown's railway history that the town was served by just a single, daily passenger train.

Pennsylvania Route 103 is a 30.8-mile (49.57 km) long north–south designated state route in the Commonwealth of Pennsylvania. Its primary course is along the south/east side of the Juniata River, while U.S. Route 522 runs along the opposite side. PA 103's southern terminus is an at-grade intersection with US 522 at Allenport in Shirley Township, a bit south of US 522's bridge across the Juniata River in Mount Union. Its northern terminus is an intersection with US 22 Business in Lewistown. It intersects the northern terminus of PA 333 just south of Juniata Terrace.