The Lexington-Fayette metropolitan area is the 109th-largest metropolitan statistical area (MSA) in the United States. It was originally formed by the United States Census Bureau in 1950 and consisted solely of Fayette County until 1980 when surrounding counties saw increases in their population densities and the number of their residents employed within Lexington-Fayette, which led to them meeting Census criteria to be added to the MSA.

Fayette County is located in the central part of the U.S. state of Kentucky and is consolidated with the city of Lexington. As of the 2020 census, the population was 322,570, making it the second-most populous county in the commonwealth. Since 1974, its territory, population and government have been shared with Lexington. Fayette County is part of the Lexington-Fayette, KY Metropolitan Statistical Area.