The Lexington Avenue/51st Street station is a New York City Subway station complex on the IRT Lexington Avenue Line and IND Queens Boulevard Line. The station is located on Lexington Avenue and stretches from 51st Street to 53rd Street in Midtown Manhattan. It is served by the 6 and E trains at all times; the M train on weekdays during the day; the <6> train during weekdays in the peak direction; and the 4 train during late nights.

The IRT Lexington Avenue Line is one of the lines of the A Division of the New York City Subway, stretching from Lower Manhattan north to 125th Street in East Harlem. The line is served by the 4, ​5, ​6, and <6> trains.